Related Experiment Video
Updated: Oct 18, 2025

Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Pd-Catalyzed allylic C-H activation to seven-membered N,O-heterocycles
Álvaro Velasco-Rubio1, Jesús A Varela1, Carlos Saá1
1Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CiQUS), Departamento de Química Orgánica, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain. carlos.saa@usc.es.
Abstract:
Pd-catalyzed allylic C-H activation of simple olefins allows an easy entry to seven-membered N,O-heterocycles such as 1,4-benzoxazepines (1,4-BZOs), 1,4-benzodiazepinones (1,4-BZDs) and 1,4-oxazepanes in good to excellent yields. Straightforward derivatization of the olefinated 1,4-BZO shows the synthetic utility of this methodology.
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