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Updated: Oct 18, 2025
15:43
Assessment of Mitochondrial Functions and Cell Viability in Renal Cells Overexpressing Protein Kinase C Isozymes
Published on: January 7, 2013
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Redox-sensitive signaling pathways in renal cell carcinoma
Alfredo Cruz-Gregorio1, Ana Karina Aranda-Rivera2, José Pedraza-Chaverri2
1Laboratorio F-225, Departamento de Biología, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México, Mexico.
Biofactors (Oxford, England)
|September 30, 2021
Summary
Renal cell carcinoma (RCC) is a lethal cancer often resistant to standard treatments. This review explores how oxidative stress and altered redox-sensitive pathways contribute to RCC, suggesting new therapeutic targets.
Area of Science:
- Oncology
- Urological Cancers
- Molecular Biology
Background:
- Renal cell carcinoma (RCC) is a deadly cancer with poor treatment outcomes.
- Obesity and smoking are key risk factors linked to oxidative stress in RCC.
- Current systemic therapies for advanced RCC remain insufficient.
Purpose of the Study:
- To review the role of redox-sensitive signaling pathways in RCC development and progression.
- To identify potential therapeutic targets within these pathways for redox therapy.
Main Methods:
- Literature review of studies on redox-sensitive molecules and signaling pathways in RCC.
- Focus on pathways including MAPK, AKT/TSC2/mTORC1, AKT/GSK3/β-catenin, NF-κB/IκB/EGFR, and PKCζ/CUTL1/HIF.
Main Results:
- Alterations in these redox-sensitive pathways are implicated in RCC.
- These pathways play roles in RCC development and maintenance.
- Specific pathways present potential targets for novel redox-based therapies.
Conclusions:
- Redox-sensitive signaling pathways are critical in renal cell carcinoma.
- Targeting these pathways offers a promising avenue for developing effective redox therapies against RCC.
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