Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Synthetic Biology

Synthetic Biology

Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
Golden rice
Golden rice is a genetically modified...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Efficient Dual Surface Modification of Cellulose Nanocrystals with Hydrophobic Moieties and Functional Polymers via a Grafting-to Approach.

Biomacromolecules·2025

Same journal

Lipid Metabolic Labeling to Study Site- and Lipid-Specific Long-Chain <i>S</i>-Acylation Dynamics.

ACS chemical biology·2026

Same journal

Inositol Thiophosphates as Inhibitors of Mammalian, Plant, and Fungal Phytases.

ACS chemical biology·2026

Same journal

Synthesis and Characterization of the Spectroscopic and Imaging Utilities of Two Indole-Based Cyan Fluorescent Nucleoside Analogues.

ACS chemical biology·2026

Same journal

Indole Ring Expansion and Rearrangement-Enabled Quinoline Scaffold Formation in the Biosynthesis of the Antitumor Monoterpene Indole Alkaloid Camptothecin.

ACS chemical biology·2026

Same journal

Intracellular Delivery of Peptides and Proteins with an Engineered Membrane Translocation Domain.

ACS chemical biology·2026

Same journal

Development of Next-Generation Fluoroacetamidine-Containing Activity-Based Probes for the Selective Labeling of the Protein Arginine Deiminases (PADs).

ACS chemical biology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Oct 18, 2025

Metabolic Glycoengineering of Sialic Acid Using N-acyl-modified Mannosamines

Metabolic Glycoengineering of Sialic Acid Using N-acyl-modified Mannosamines

Published on: November 25, 2017

Engineering the Sialome.

Landon J Edgar¹

¹Department of Pharmacology and Toxicology, The University of Toronto, Toronto, Ontario, Canada, M5S 1A8.

ACS Chemical Biology

|September 30, 2021

Summary

This summary is machine-generated.

Scientists are exploring ways to modify the cell surface

More Related Videos

Protein Engineering by Yeast Surface Display

Protein Engineering by Yeast Surface Display

Published on: November 29, 2024

Visualizing Intracellular Sialylation with Click Chemistry and Expansion Microscopy

Visualizing Intracellular Sialylation with Click Chemistry and Expansion Microscopy

Published on: February 7, 2025

Related Experiment Videos

Last Updated: Oct 18, 2025

Metabolic Glycoengineering of Sialic Acid Using N-acyl-modified Mannosamines

Metabolic Glycoengineering of Sialic Acid Using N-acyl-modified Mannosamines

Published on: November 25, 2017

Protein Engineering by Yeast Surface Display

Protein Engineering by Yeast Surface Display

Published on: November 29, 2024

Visualizing Intracellular Sialylation with Click Chemistry and Expansion Microscopy

Visualizing Intracellular Sialylation with Click Chemistry and Expansion Microscopy

Published on: February 7, 2025

Area of Science:

Glycobiology
Cell Biology
Biochemistry

Background:

Eukaryotic cell surfaces feature a complex glycocalyx, a dense layer of diverse glycans.
This glycocalyx acts as a crucial interface between cellular processes and the external environment.
Sialic acids, a family of anionic monosaccharides, are common terminal glycans within the glycocalyx.

Purpose of the Study:

To review current strategies for altering the cellular sialic acid composition, known as the sialome.
To focus on the glycan structures involved in these modifications.
To highlight state-of-the-art tools used for sialome editing.

Main Methods:

Review of metabolic strategies for sialome modification.
Review of enzymatic approaches for sialome editing.
Review of chemical methods for altering cellular sialic acid content.

Main Results:

Multiple strategies exist to modify the sialome, targeting glycan structures.
Various tools and techniques are available for precise sialome composition alteration.
Advances enable detailed study and manipulation of cell surface glycans.

Conclusions:

Understanding and manipulating the sialome is critical for studying cell-cell interactions.
Metabolic, enzymatic, and chemical methods offer powerful approaches to edit the sialome.
Continued development of tools will advance research in glycobiology and cell surface engineering.