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Peritoneal Pre-conditioning Method for In Vivo Vascular Graft Maturation Utilizing a Porous Pouch
Mahyar Sameti1, Chris A Bashur2
1Department of Biomedical, Chemical Engineering, and Science, Florida Institute of Technology, Melbourne, FL, USA.
Methods in Molecular Biology (Clifton, N.J.)
|September 30, 2021
Summary
This study introduces a novel hydrogel pouch for electrospun conduits, using the peritoneal cavity as a bioreactor. This approach recruits autologous cells to improve tissue-engineered vascular grafts (TEVGs) for aortic repair.
Area of Science:
- Biomedical Engineering
- Regenerative Medicine
- Vascular Surgery
Background:
- Tissue-engineered vascular grafts (TEVGs) face challenges like stenosis and mechanical failure.
- Intimal hyperplasia and thrombosis remain significant concerns for small-diameter arterial grafts.
Purpose of the Study:
- To develop a strategy using the peritoneal cavity as an in vivo bioreactor for TEVG enhancement.
- To create a novel hydrogel pouch for electrospun conduits to facilitate cell recruitment and improve aortic grafting outcomes.
Main Methods:
- Utilizing the peritoneal cavity to recruit autologous cells to electrospun conduits.
- Designing a hydrogel pouch to enclose conduits, preventing adhesion while allowing cell and fluid infiltration.
Main Results:
- The hydrogel pouch strategy aims to improve the in vivo response of vascular grafts.
- The design facilitates peritoneal fluid and cell infiltration for enhanced graft integration.
Conclusions:
- The peritoneal cavity can serve as an effective in vivo bioreactor for TEVG development.
- The novel hydrogel pouch design offers a promising approach to mitigate complications in aortic grafting.
