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Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
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Injectable Hydrogels for Vascular Tissue Engineering.

Fengqiao Li1, William Ho1, Xiaoyang Xu2,3

  • 1Department of Chemical and Materials Engineering, New Jersey Institute of Technology, Newark, NJ, USA.

Methods in Molecular Biology (Clifton, N.J.)
|September 30, 2021
PubMed
Summary
This summary is machine-generated.

A novel injectable hydrogel releases citrate and myeloid-derived growth factor (Mydgf) to repair heart damage after myocardial infarction (MI). This biodegradable scaffold reduces scar size and improves cardiac function in a rat model.

Keywords:
Cardiac remodelingInjectable hydrogelMydgfMyocardial infarction (MI )

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Area of Science:

  • Biomaterials Science
  • Cardiovascular Research
  • Regenerative Medicine

Background:

  • Myocardial infarction (MI) leads to significant cardiac damage and impaired heart function.
  • Biodegradable injectable scaffolds offer a promising strategy for cardiac repair and stabilization.
  • Current approaches require further development for enhanced therapeutic efficacy.

Purpose of the Study:

  • To develop and characterize an injectable, citrate-containing polyester hydrogel for myocardial repair.
  • To investigate the combined therapeutic effects of released citrate and encapsulated myeloid-derived growth factor (Mydgf).
  • To evaluate the efficacy of this hydrogel in a rat model of myocardial infarction.

Main Methods:

  • Synthesis of a biodegradable polyester hydrogel using citric acid and poly(ethylene glycol) diol.
  • Characterization of hydrogel properties including degradation, mechanical strength, and drug release kinetics.
  • Intramyocardial injection of Mydgf-loaded hydrogel in a rat MI model.
  • Histological analysis (H&E, Masson's trichrome) and immunohistochemistry to assess cardiac structure, scar formation, and neovascularization.

Main Results:

  • The developed hydrogel demonstrated tunable degradation and mechanical properties with sustained Mydgf release.
  • Intramyocardial injection significantly reduced infarct size and cardiac scar formation.
  • Treatment led to increased cardiac wall thickness and enhanced neovascularization.
  • Improved overall heart function was observed in the treated rat MI model.

Conclusions:

  • Injectable citrate-containing polyester hydrogels are effective in promoting cardiac repair post-MI.
  • The combination of citrate and Mydgf delivered via hydrogel enhances therapeutic outcomes.
  • This novel scaffold represents a promising therapeutic strategy for myocardial regeneration and functional recovery.