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Updated: Oct 18, 2025

A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma

A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma

Published on: January 5, 2017

Recurrent neck myxofibrosarcoma: a case report.

Chiara Pagnoni¹, Luca Improta², Rossana Alloni¹

¹Campus Bio-Medico University of Rome, Via Alvaro del Portillo, 200 - 00128, Roma, RM, Italy.

Journal of Medical Case Reports

|October 1, 2021

Summary

This summary is machine-generated.

This case study highlights the successful use of preoperative radiotherapy (RT) and surgery for head and neck myxofibrosarcoma (MFS). Combined treatment led to no recurrence in a 24-month follow-up, suggesting RT

Keywords:

Myxofibrosarcoma (MFS)Preoperative radiotherapy Sarcoma referral centers (SRCs)Soft tissue sarcoma (STS)Wide surgical margins

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Area of Science:

Oncology
Surgical Oncology
Radiation Oncology

Background:

Myxofibrosarcoma (MFS) is a rare soft tissue sarcoma primarily affecting elderly men, characterized by high recurrence rates and low metastatic potential.
Head and neck MFS are exceptionally rare, with surgery being the primary treatment modality, although the roles of radiotherapy (RT) and chemotherapy (CHT) remain under investigation.

Observation:

A 67-year-old male patient with a history of MFS in the neck, previously excised with positive margins, presented for further treatment.
Staging revealed no distant metastasis. A multidisciplinary team recommended preoperative RT (50 Gy) followed by wide surgical excision.

Findings:

Histological examination post-surgery confirmed the absence of viable tumor cells.
The patient experienced no relapse during a 24-month postoperative follow-up period.

Implications:

This case suggests that a planned combined treatment approach involving RT and surgery may be beneficial for high-grade soft tissue sarcomas, particularly MFS.
Radiotherapy shows promise as an adjuvant treatment for head and neck MFS, warranting further investigation into its role in improving disease-free and overall survival.