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New Treatments for Chronic Hepatitis B Virus/Hepatitis D Virus Infection

Lisa Sandmann1, Heiner Wedemeyer2

  • 1Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Carl-Neuberg-Str. 1, Hannover 30625, Germany.

Clinics in Liver Disease
|October 1, 2021
PubMed

Insights

Chronic hepatitis D virus (HDV) infection, the most severe hepatitis form, necessitates new treatments. Promising antiviral therapies, including bulevirtide, are now available or in development.

Area of Science:

  • Hepatology
  • Virology
  • Infectious Diseases

Background:

  • Chronic hepatitis D virus (HDV) infection is a severe liver disease.
  • It has high rates of end-stage liver disease and hepatocellular carcinoma.
  • Current treatment options are limited.

Purpose of the Study:

  • To review the current landscape of antiviral treatment strategies for chronic HDV infection.
  • To highlight newly approved and investigational therapies.

Main Methods:

  • Review of recent clinical trials and regulatory approvals.
  • Analysis of emerging antiviral compounds targeting HDV.

Main Results:

  • Pegylated interferon-alpha was the primary treatment until recently.
  • Bulevirtide, an entry inhibitor, received conditional approval.
  • Multiple other antiviral agents are in Phase II and III trials.

Conclusions:

  • New antiviral treatment options for chronic HDV infection are now available.
  • Investigational therapies show promise for managing this severe liver disease.
Keywords:
Antiviral treatmentBulevirtideHepatitis deltaInterferonInterferon lambdaNucleic acid polymerssiRNA

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