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IntroductionUltrasonography, or renal ultrasound, is a noninvasive medical imaging technique that uses high-frequency sound waves to visualize the kidneys, ureters, bladder, and surrounding tissues.Indications for Urinary System UltrasonographyUrinary system ultrasonography is indicated in various clinical scenarios, such as:Kidney Stones (Urolithiasis): To detect and monitor the size and presence of kidney or urinary tract stones.Hydronephrosis: To assess the dilation of the renal pelvis and...

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Updated: Oct 18, 2025

Sonodynamic Therapy for the Treatment of Glioblastoma Multiforme in a Mouse Model Using a Portable Benchtop Focused Ultrasound System

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Molecular Imaging-Guided Sonodynamic Therapy.

Juan Guo¹, Xueting Pan¹, Chaohui Wang¹

¹Beijing Advanced Innovation Center for Soft Matter Science and Engineering, State Key Laboratory of Organic-Inorganic Composites, Beijing Laboratory of Biomedical Materials, Bionanomaterials & Translational Engineering Laboratory, Beijing Key Laboratory of Bioprocess, Beijing University of Chemical Technology, Beijing 100029, P.R. China.

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|October 1, 2021

Summary

This summary is machine-generated.

Molecular imaging-guided sonodynamic therapy (SDT) offers precise, noninvasive treatment. Nanoparticle sonosensitizers enhance efficacy for cancer, infections, and vascular diseases by enabling real-time monitoring.

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Area of Science:

Biomedical Engineering
Nanotechnology
Oncology
Medical Imaging

Background:

Sonodynamic therapy (SDT) is a noninvasive treatment using low-intensity ultrasound.
Nanotechnology has advanced SDT with nanoparticle sonosensitizers.
Personalized medicine demands precise therapeutic window determination.

Purpose of the Study:

To review molecular imaging-guided sonodynamic therapy (SDT).
To discuss SDT mechanisms and nanoparticle design for imaging.
To summarize applications in cancer, infections, and vascular diseases.

Main Methods:

Discussion of prevalent SDT mechanisms: ultrasonic cavitation, sonoluminescence, reactive oxygen species, and mechanical damage.
Introduction to major molecular imaging techniques.
Principles of nanoparticle design for efficient imaging in SDT.

Main Results:

Novel sonosensitizers with imaging capabilities enhance treatment efficacy.
Imaging-guided SDT shows promise for treating cancer, bacterial infections, and vascular diseases.
Nanoparticle-based approaches facilitate efficient molecular imaging for SDT.

Conclusions:

Molecular imaging-guided SDT represents a significant advancement in noninvasive therapeutics.
Further development is needed for more effective modalities and clinical translation.
This approach offers novel strategies for precise and personalized disease treatment.