Prucalopride in intestinal pseudo obstruction, paediatric experience and systematic review
M Mutalib1, J Kammermeier1, R Vora1
1Department of Paediatric Gastroenterology, Evelina London Children's Hospital, London, UK.
Insights
Prucalopride shows promising results for treating intestinal pseudo obstruction, a severe motility disorder. This study reviewed its effectiveness in children and adults, finding clinical improvement in all reported cases.
Area of Science:
- Gastroenterology
- Pharmacology
- Pediatric Medicine
Background:
- Intestinal pseudo obstruction is a severe, uncommon motility disorder affecting all ages with no standard treatment.
- Prucalopride, a selective serotonin receptor agonist, is known for its laxative effects and potential extra-colonic actions.
Purpose of the Study:
- To report clinical experience with prucalopride in pediatric patients suffering from acute and chronic intestinal pseudo obstruction.
- To conduct a systematic review on the efficacy of prucalopride in managing intestinal pseudo obstruction across age groups.
Main Methods:
- A clinical case series approach was employed.
- A systematic review of medical databases was performed to identify studies on prucalopride use in intestinal pseudo obstruction.
- Included studies encompassed full texts, abstracts, and case reports.
Main Results:
- All documented cases demonstrated a positive clinical response to prucalopride.
- A total of eight reports were reviewed, including three full texts, two abstracts, and three case reports.
- Consistent clinical improvement was observed in patients treated with prucalopride.
Conclusions:
- Prucalopride exhibits promising therapeutic potential for both acute and chronic intestinal pseudo obstruction in pediatric and adult populations.
- Further research may solidify prucalopride's role in the management of this challenging motility disorder.
Background:
Intestinal pseudo obstruction both acute and chronic is an uncommon severe motility disorder that affect both children and adults, can lead to significant morbidity burden and have no standard management strategy. Prucalopride a highly selective serotonin receptor agonist is an effective laxative with reported extra colon action. We aim to report our experience in children with acute and chronic intestinal pseudo obstruction who responded to prucalopride and systemically review the use of prucalopride in intestinal pseudo obstruction.
Methods:
A report of clinical experience and systemic review of the relevant medical databases to identify the outcome of usage of prucalopride in patients with acute and chronic intestinal pseudo obstruction. Studies meeting the selection criteria were reviewed including abstract only and case reports.
Results:
All reported cases showed clinical response to prucalopride. There were three full text, two abstracts only and three case reports all reporting clinical improvement with prucalopride.
Conclusion:
Prucalopride appears to show promising results in children and adults with acute and chronic intestinal pseudo obstruction.
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