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Updated: Oct 18, 2025

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
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Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2

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Coronavirus Disease 2019

Sophie Lin1, Rachael Kantor2, Elizabeth Clark3

  • 1New York Medical College, Metropolitan Hospital Center, 1901 First Avenue, New York, NY, 10029, USA.

Clinics in Geriatric Medicine
|October 3, 2021
PubMed

Insights

This review covers COVID-19 in older adults, highlighting increased risks due to aging factors and the impact of control measures. It also details necessary health system improvements for this vulnerable population.

Area of Science:

  • Gerontology
  • Infectious Diseases
  • Public Health

Background:

  • Aging physiology and comorbidities increase susceptibility to severe COVID-19.
  • Seniors face unique challenges in managing viral infections.
  • Understanding age-related risks is crucial for effective pandemic response.

Observation:

  • COVID-19 presents distinct manifestations in older adults.
  • Viral spread is exacerbated by factors common in senior populations.
  • Public health interventions can negatively impact seniors' well-being.

Findings:

  • Older adults exhibit increased pathogenicity due to aging.
  • Specific factors contribute to rapid COVID-19 transmission among seniors.
  • Control measures have unintended consequences on elderly health.

Implications:

  • Health systems require targeted improvements for elder care during pandemics.
  • Proactive strategies are needed to mitigate risks for older adults.
  • Protecting vulnerable populations necessitates adaptive healthcare approaches.

Keywords:
AgeismCOVID-19ComorbiditiesElderlyNursing homesRacismTelemedicine

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