Soluble LAG-3 and Toll-interacting protein: Novel upstream neuro-inflammatory markers in Parkinson's disease
Akash Roy1, Supriyo Choudhury2, Rebecca Banerjee2
1Department of Neurology, Institute of Neurosciences Kolkata, Kolkata, India; Department of Physiology, University of Calcutta, Kolkata, India.
Introduction:
There is some evidence regarding the role of LAG-3, TLR mediated neuroinflammation in PD.
Methods:
sLAG-3, TOLLIP, NLRP3 levels were measured in PD and healthy controls.
Results:
These markers were significantly higher in PD and were associated with progression.
Conclusion:
sLAG3 and TOLLIP are involved in the NLRP3 mediated inflammatory activation in PD.
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