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[Mastocytes and the oral cavity. Anatomy and function]
Revue De Stomatologie Et De Chirurgie Maxillo-Faciale
|January 1, 1986
Summary
Mast cells are present in chronic dental lesions and contribute to inflammation and immune responses. Understanding their biochemical actions may clarify pain mechanisms in dental crises.
Area of Science:
- Oral pathology
- Immunohistochemistry
- Mast cell biology
Context:
- Investigated mast cells in 103 teeth with chronic pulpitis, 12 chronic periapical lesions, and 11 oral soft tissue biopsies.
- Examined the presence, anatomy, and function of mast cells in various chronic oral conditions.
Purpose:
- To elucidate the role of mast cells in chronic dental inflammation and lesions.
- To explore the contribution of mast cells to humoral and cellular immunological phenomena in the oral cavity.
Summary:
- Mast cells induce early inflammation via histamine release, leading to venule dilatation.
- Observed mast cells in all chronic lesions, highlighting their involvement in collagen lysis, bone resorption, and epithelial proliferation.
- Mast cells participate in both humoral and cellular immune responses within oral tissues.
Impact:
- Enhanced understanding of mast cell biochemical actions can elucidate dental pain mechanisms.
- Provides insights into inflammatory processes in chronic pulpitis and periapical lesions.
- Contributes to the knowledge base for managing chronic oral inflammatory and immune conditions.