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Updated: Oct 18, 2025

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

Multi-responsive PNIPAM-PEGDA hydrogel composite.

Liqian Wang¹, Fengrui Liu¹, Jin Qian¹

¹State Key Laboratory of Fluid Power & Mechatronic System, Key Laboratory of Soft Machines and Smart Devices of Zhejiang Province, Department of Engineering Mechanics, Zhejiang University, Hangzhou 310027, China. jqian@zju.edu.cn.

|October 4, 2021

Summary

This summary is machine-generated.

Researchers developed a 3D-printed hydrogel bilayer that changes shape with temperature, solvent, and magnetic fields. This multi-responsive material offers advanced control for soft robots and sensors.

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Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

Published on: April 16, 2018

Area of Science:

Materials Science
Polymer Science
Robotics

Background:

Hydrogels are crucial for soft robots and sensors due to environmental responsiveness.
Developing hydrogels with multiple response capabilities is a significant challenge.
Existing hydrogels often lack multi-stimuli responsiveness for complex applications.

Purpose of the Study:

To fabricate a novel multi-responsive hydrogel bilayer using 3D printing.
To investigate the shape-changing capabilities of the hydrogel in response to temperature, solvent composition, and magnetic fields.
To create advanced actuators and sensors with tunable deformation.

Main Methods:

Utilized 3D printing to create a bilayer hydrogel composed of thermo-responsive PNIPAM and PEGDA.
Investigated the swelling behavior of PNIPAM gels with temperature and ethanol-water mixtures.
Incorporated Fe3O4 nanoparticles into PEGDA for magnetic field responsiveness.

Main Results:

The PNIPAM-PEGDA bilayer exhibited controlled bending based on temperature and solvent composition changes.
PNIPAM gels showed thermo-responsiveness and cononsolvency effects in ethanol-water mixtures.
The Fe3O4-doped PEGDA component enabled magnetic field-induced deformation and motion.

Conclusions:

The 3D-printed PNIPAM-PEGDA hydrogel bilayer demonstrates versatile multi-stimuli responsiveness.
This material enables precise shape control for advanced applications in soft robotics and flexible sensors.
The integration of magnetic nanoparticles provides an additional degree of freedom for actuation.