Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Past present and future of radiosensitization in cervical cancer.

Frontiers in oncology·2026
Same author

Radiation Quality and Workflow in NRG GY017: Anti-PD-L1 (Atezolizumab) as an Immune Primer or Concurrently With Radiation Therapy for Node-Positive Locally Advanced Cervical Cancer.

International journal of radiation oncology, biology, physics·2026
Same author

American Brachytherapy Society consensus guidelines for medical physics residency training endorsed by the American Association of Physicists in Medicine, Part I: High-dose-rate remote afterloader brachytherapy.

Brachytherapy·2026
Same author

Rapid Artificial Intelligence Autoplanning Rivals Manual Expert Planning for Cervical Brachytherapy.

Practical radiation oncology·2026
Same author

Development and evaluation of a cervical cancer-specific restriction spectrum imaging (RSI) model.

Magnetic resonance imaging·2026
Same author

Systematic effects of patient factors and scanner/protocol factors on a Restriction Spectrum Imaging (RSI) quantitative MRI biomarker for prostate cancer.

Cancer imaging : the official publication of the International Cancer Imaging Society·2026

Related Experiment Video

Updated: Oct 18, 2025

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

20.6K

Evaluation of dose differences between intracavitary applicators for cervical brachytherapy using knowledge-based

Karoline Kallis1, Jyoti Mayadev1, Brent Covele1

  • 1Department of Radiation Medicine and Applied Sciences, University of California San Diego, San Diego, CA.

Brachytherapy
|October 5, 2021
PubMed
Summary
This summary is machine-generated.

This study developed accurate knowledge-based models for brachytherapy planning in cervical cancer, showing the tandem-and-ring (T&R) applicator offers superior organ-at-risk (OAR) sparing compared to tandem-and-ovoids (T&O).

Keywords:
Cervical cancerDose predictionIntracavitary brachytherapyKnowledge-based planningTandem and ovoidsTandem and ring

More Related Videos

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition
06:20

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition

Published on: March 11, 2021

7.4K
Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification ADCI and Dose Estimation
10:33

Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification ADCI and Dose Estimation

Published on: September 4, 2017

15.9K

Related Experiment Videos

Last Updated: Oct 18, 2025

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

20.6K
Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition
06:20

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition

Published on: March 11, 2021

7.4K
Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification ADCI and Dose Estimation
10:33

Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification ADCI and Dose Estimation

Published on: September 4, 2017

15.9K

Area of Science:

  • Medical Physics
  • Radiation Oncology
  • Oncology

Background:

  • Patient-specific tools are lacking for cervical cancer brachytherapy planning and applicator selection.
  • Knowledge-based models offer a potential solution for improving treatment precision and outcomes.

Purpose of the Study:

  • To evaluate the accuracy of organ-at-risk (OAR) dose predictions using knowledge-based intracavitary models.
  • To determine dosimetric differences between tandem-and-ring (T&R) and tandem-and-ovoids (T&O) applicators using these models and clinical data.

Main Methods:

  • Knowledge-based models were trained and validated for T&R and T&O applicators, predicting organ D2cc.
  • Model performance was assessed by precision (σ(ΔD2cc)).
  • Dosimetric differences were evaluated by applying models across applicator types and comparing with clinical data using Student's t-test.

Main Results:

  • Validation precision for T&R/T&O models was 0.55/0.65 Gy (bladder), 0.38/0.55 Gy (rectum), and 0.60/0.43 Gy (sigmoid).
  • T&R applicators showed significantly lower predicted OAR D2cc values (e.g., 7.31 Gy for rectum) compared to T&O.
  • Clinical data corroborated model predictions, indicating lower T&R OAR doses, especially for the rectum (p < 0.01).

Conclusions:

  • Accurate knowledge-based dose prediction models for intracavitary brachytherapy applicators were successfully developed.
  • These models can aid in standardizing and enhancing brachytherapy plan quality.
  • Both model predictions and clinical data suggest T&R applicators provide superior OAR sparing over T&O, particularly for the rectum.