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Published on: June 5, 2020
The Association Between Dimethylacetamide Exposure and Liver Toxicity: A Large Retrospective Analysis in Workers From
Evangelia E Antoniou1, Heinz-Peter Gelbke, Jochen Ballach
1MetaAnalyses.com, Hees, Belgium (Dr Antoniou); CinTox, Mannheim, Germany (Dr Gelbke); Industrievereinigung Chemiefaser e.V. (IVC) and Treuhandgemeinschaft Deutscher Chemiefasererzeuger (TDC), Frankfurt am Main, Germany (Dr Ballach); School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, The Netherlands (Dr Zeegers); Care and Public Health Research Institute, Maastricht University, Maastricht, The Netherlands (Dr Zeegers); MyBasePair Holding, Heerlen, The Netherlands (Dr Zeegers); and BASF SE, Ludwigshafen am Rhein, Germany (Dr Schrage).
Objective:
This study examines the association between 8-h time weighted N, N-dimethylacetamide (DMAc) air exposure and potential hepatocellular injury in a retrospective study among fibre-production workers in four European factories.
Methods And Results:
Twenty-nine (1.5%) of 1844 alanine aminotransferase (ALT) observations had liver values two times above normal; 0.2% three times above normal and 0.05% five times above normal. Two (0.1%) observations were indicative of hepatocellular injury. Logistic regression analyses showed an odds ratio for elevated ALT of 0.88 per 1 ppm (P trend = 0.39). Linear random effects regression analyses showed a decrease of one international unit (IU/L) ALT per 1 ppm increase of DMAc exposure (P = 0.002).
Conclusions:
This study found no association between DMAc exposure and hepatoxicity amongst European workers. The prevalence of elevated liver values was lower compared to the general population without occupational exposure.
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