Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

753
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
753
Glaucoma: Overview01:25

Glaucoma: Overview

981
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
981
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

889
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
889
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

21
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
21

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The impact of treatment modality on quality of life in glaucoma patients: findings from a clinical survey study in Augusta, GA.

International ophthalmology·2025
Same author

A Multitrait Polygenic Risk Score for Open-Angle Glaucoma Stratifies Risk of Pigmentary Glaucoma in Pigment Dispersion Syndrome.

Ophthalmology. Glaucoma·2025
Same author

Difluprednate achieves a similar clinical outcome after trabeculectomy compared to prednisolone acetate at a significantly lower drop frequency.

Therapeutic advances in ophthalmology·2025
Same author

Advancing glaucoma management: Innovation, collaboration, and future directions.

Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological Society·2025
Same author

Evaluation of Reproducibility of Measurements of Peripapillary Blood Flow with Laser Speckle Flowgraphy in Healthy and POAG Subjects.

Klinische Monatsblatter fur Augenheilkunde·2024
Same author

Swiss Multicenter Ab Interno XEN45 Gel Stent Study: 2-Year Real-World Data.

Ophthalmology and therapy·2024

Related Experiment Video

Updated: Oct 18, 2025

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis
13:47

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis

Published on: June 3, 2018

9.5K

[Structure/function/treatment in glaucoma: progress over the last 10 years].

Frances Meier-Gibbons1, Marc Töteberg-Harms2

  • 1Augenzentrum Rapperswil, Merkurstr. 50, 8640, Rapperswil, Schweiz. frances.meier@bluewin.ch.

Der Ophthalmologe : Zeitschrift Der Deutschen Ophthalmologischen Gesellschaft
|October 5, 2021
PubMed
Summary

Landmark glaucoma studies like OHTS and CIGTS guide treatment decisions. Research shows lowering intraocular pressure (IOP) can slow glaucoma progression, and surgery may be suitable for advanced cases.

Keywords:
Intraocular pressureLandmark studiesLatanoprostScreeningVisual field

More Related Videos

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation
08:30

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation

Published on: March 12, 2016

13.3K
Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
10:10

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

1.6K

Related Experiment Videos

Last Updated: Oct 18, 2025

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis
13:47

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis

Published on: June 3, 2018

9.5K
Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation
08:30

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation

Published on: March 12, 2016

13.3K
Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
10:10

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

1.6K

Area of Science:

  • Ophthalmology
  • Clinical Trials
  • Glaucoma Management

Background:

  • Landmark multicenter, randomized, and masked studies since the 1990s have significantly impacted glaucoma patient management.
  • Key studies include the Ocular Hypertension Treatment Study (OHTS) and the Collaborative Initial Treatment Glaucoma Study (CIGTS), crucial for conservative management and structure-function evaluation.

Purpose of the Study:

  • To evaluate the impact of intraocular pressure (IOP) lowering treatments on glaucoma progression.
  • To compare pharmacotherapy versus surgical treatment for glaucoma.
  • To assess the efficacy of latanoprost in managing visual field defects and to evaluate glaucoma screening tests.

Main Methods:

  • The Ocular Hypertension Treatment Study (OHTS) investigated risk factors and IOP reduction's effect on primary open-angle glaucoma progression.
  • The Collaborative Initial Treatment Glaucoma Study (CIGTS) compared pharmacotherapy and surgical interventions.
  • The United Kingdom Glaucoma Treatment Study (UKGTS) and Glaucoma Automated Test Evaluation (GATE) examined latanoprost's effects and screening test utility, respectively.

Main Results:

  • OHTS findings support both prophylactic treatment and watchful waiting strategies for ocular hypertension.
  • CIGTS indicated that surgery can be a viable option for newly diagnosed moderate to advanced glaucoma under specific conditions.
  • UKGTS demonstrated that latanoprost reduces IOP and slows visual field defect progression in early to moderate glaucoma.
  • GATE found no clear benefit of screening examinations, questioning their cost-effectiveness and diagnostic yield.

Conclusions:

  • Treatment decisions for glaucoma should consider individual risk factors and disease severity.
  • Lowering intraocular pressure is a key strategy in managing glaucoma progression.
  • While screening tests have limitations, specific treatments like latanoprost show efficacy in preserving visual function.