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Updated: Oct 18, 2025
Fluorescence Molecular Tomography for In Vivo Imaging of Glioblastoma Xenografts
Published on: April 26, 2018
[Morphological evaluation of the effectiveness of fluorescence navigation with chlorin e6 in surgery for malignant
A Yu Rynda1, Yu M Zabrodskaya1, V E Olyushin1
1Prof. A.L. Polenov Russian Neurosurgical Institute - Branch V.A. Almazov National Medical Research Center of the Ministry of Health of Russia, Saint Petersburg, Russia.
Objective:
To evaluate the effectiveness of fluorescence navigation with chlorin e6 in surgery for malignant gliomas based on surgical material morphological and immunohistochemical data.
Material And Methods:
The surgical material obtained from patients with high-grade (Grade III-IV) anaplastic glioma was examined. Along with histological examination, the proliferation marker Ki-67, the cell cycle transcription factor protein p53, and vascular endothelial growth factor (VEGF) were determined.
Results:
A significant direct correlation was found between the expression of Ki-67, p53, and VEGF and the fluorescence intensity of tumor tissues (p<0.05).
Conclusion:
The technique of fluorescence navigation using chlorin e6 in comparative morphopathological analysis has confirmed its effectiveness in surgery for malignant gliomas.
