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In Vitro Multiparametric Cellular Analysis by Micro Organic Charge-modulated Field-effect Transistor Arrays

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Organic Bioelectronic Devices for Metabolite Sensing.

Anil Koklu¹, David Ohayon¹, Shofarul Wustoni¹

¹King Abdullah University of Science and Technology (KAUST), Biological and Environmental Science and Engineering (BESE), Organic Bioelectronics Laboratory, Thuwal 23955-6900, Saudi Arabia.

Chemical Reviews

|October 5, 2021

Summary

Organic electronic sensors offer promising solutions for detecting essential metabolites, crucial for diagnosing and monitoring health conditions. This review explores advanced organic electronic materials and strategies for metabolite sensing applications.

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Area of Science:

Bioelectronics
Materials Science
Analytical Chemistry

Background:

Electrochemical detection of metabolites is vital for disease diagnosis and health monitoring.
Current metabolite detection methods face challenges in sensitivity, selectivity, and real-time monitoring.
Organic electronic materials present a novel platform for developing advanced biosensors.

Purpose of the Study:

To review organic electronic material-based sensors for metabolite detection.
To highlight the potential of these sensors in addressing current detection challenges.
To provide a comprehensive overview of materials, strategies, and applications.

Main Methods:

Overview of organic electronic materials and biorecognition units.
Explanation of various electrochemical detection strategies.
Benchmarking of state-of-the-art sensors across different application areas (in vitro, body-interfaced, in vivo, cell-interfaced).

Main Results:

Categorization of sensors based on application areas.
Identification of advantages and disadvantages of different organic electronic materials and detection strategies.
Analysis of current technological limitations and future potential.

Conclusions:

Organic bioelectronic materials hold significant promise for metabolite sensing.
Further research is needed to overcome challenges in device stability, integration, and long-term performance.
Advancements in organic electronic metabolite sensors will enable improved diagnostics and continuous health monitoring.