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Obesity as a Thrombogenic and Cardiovascular Risk Factor in Children
Louise Cominato1, Ruth Rocha Franco1, Marina Ybarra1
1Instituto da Criança, São Paulo, Brazil.
Hormone Research in Paediatrics
|October 5, 2021
Summary
Childhood obesity is linked to a prothrombotic state, increasing the risk of blood clots. This study found higher thrombin generation and fibrinogen levels in obese children, indicating a heightened thrombogenic risk during the prepubertal phase.
Area of Science:
- Pediatric Endocrinology
- Hematology
- Metabolic Disorders
Background:
- Obesity in adults is a known risk factor for thromboembolic events.
- The relationship between childhood obesity and thrombogenic risk remains understudied.
- Understanding this link is crucial for early intervention and prevention strategies.
Purpose of the Study:
- To evaluate the prothrombotic state in obese children compared to healthy peers.
- To investigate the association between obesity and markers of blood clot formation in prepubertal children.
- To identify potential early indicators of thrombotic risk in pediatric obesity.
Main Methods:
- Measurement of thrombin generation, fibrinogen, and D-dimer levels.
- Assessment of metabolic parameters in study participants.
- Comparison of these markers between obese (n=47) and eutrophic (n=25) prepubertal children.
Main Results:
- Obese children exhibited significantly increased thrombin generation.
- Elevated fibrinogen levels were observed in the obese group.
- Obese patients also showed a higher prevalence of dyslipidemia.
Conclusions:
- Childhood obesity, even in the prepubertal phase, is associated with a prothrombotic state.
- Increased thrombin generation and fibrinogen suggest a heightened risk of blood clot formation.
- These findings highlight the importance of addressing obesity in children to mitigate future thrombotic risks.
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