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Related Concept Videos

Inflammatory Bowel Disease V: Surgical Management01:21

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Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
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Chronic Pancreatitis II: Collaborative Care01:29

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Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes
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Glycemic Variability Within 1 Year Following Surgery for Stage II-III Colon Cancer.

Natalie Rasmussen Mandolfo1, Ann M Berger1, Leeza Struwe1

  • 1College of Nursing, Nebraska Medical Center, University of Nebraska Medical Center, Omaha, NE, USA.

Biological Research for Nursing
|October 6, 2021
PubMed
Summary

Patients with Type 2 Diabetes (T2D) undergoing colon cancer surgery show higher glycemic variability post-operation. This highlights the importance of monitoring blood sugar control in diabetic patients after cancer treatment.

Keywords:
colon cancerdiabetesglucoseglycemic variabilitysurgerytreatment

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Area of Science:

  • Endocrinology
  • Oncology
  • Metabolic Research

Background:

  • Glycemic variability is a critical factor in diabetes management.
  • Colon cancer treatment, including surgery, can impact metabolic health.
  • Understanding post-surgical glycemic control in cancer patients with and without Type 2 Diabetes (T2D) is essential.

Purpose of the Study:

  • To investigate glycemic variability in adult patients with and without Type 2 Diabetes (T2D) after stage II-III colon cancer surgery.
  • To compare glycemic variability at 1 month and 1 year post-surgery between T2D and non-T2D groups.

Main Methods:

  • Retrospective analysis of electronic health record data from 165 patients.
  • Assessment of glycemic variability using standard deviation (SD) and coefficient of variation (CV) of blood glucose measures.
  • Statistical analyses included Chi-square, Fisher's exact, and Mann-Whitney U tests.

Main Results:

  • Patients with T2D exhibited significantly higher glycemic variability (p < .001) at both 1 month and 1 year post-surgery compared to those without T2D.
  • In T2D patients, lower BMI correlated with higher variability within 1 month, and higher preoperative glucose correlated with higher variability within 1 year.
  • Demographic and clinical factors showed weak associations with glycemic variability in patients without T2D.

Conclusions:

  • Type 2 Diabetes status is a significant determinant of post-surgical glycemic variability in colon cancer patients.
  • Glycemic control management strategies may need to be tailored based on T2D status and other clinical factors.
  • Further prospective studies are recommended to confirm these findings and explore clinical implications.