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Updated: Oct 17, 2025

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
Visible-light-promoted olefinic trifluoromethylation of enamides with CF3SO2Na
Kai Tang1, Yixuan Chen, Jianping Guan
1College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China. hyangchem@csu.edu.cn kaichen@csu.edu.cn.
Abstract:
A visible-light-promoted olefinic C-H trifluoromethylation of enamides was developed by employing cheap and stable Langlois' reagent as the CF3 source. A series of β-CF3 enamides were obtained in moderate to good yields with high E-isomer selectivity under mild conditions. Preliminary mechanistic studies suggest that molecular oxygen acts as the terminal oxidant for this net oxidative process, and the E isomer selectivity could be well explained by a base-assisted deprotonation of the cation intermediate.
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