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Updated: Aug 6, 2025

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
Photochemical Alkene Trifluoromethylimination Enabled by Trifluoromethylsulfonylamide as a Bifunctional Reagent
Yu Zheng1, Zihao Liao1, Zhenzhen Xie1
1College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, P. R. China.
Abstract:
Herein, we disclose a facile and versatile trifluoromethylimination of alkene with a rationally designed N-(diphenylmethylene)-1,1,1-trifluoromethanesulfonamide as a bench-stable and readily accessible carboamination reagent. Enabled by an energy transfer (EnT) process, an array of alkenes were able to be facilely CF3-iminated under metal-free photocatalytic conditions. The mild reaction conditions and good functional group compatibility render this protocol highly valuable for the difunctionalization of olefins with structural complexity and diversity.
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