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CyanoOmicsDB: an integrated omics database for functional genomic analysis of cyanobacteria
Peng Zhou1, Li Wang1, Hai Liu1
1State Key Laboratory of Biocatalysis and Enzyme Engineering, Environmental Microbial Technology Center of Hubei Province, and School of Life Sciences, Hubei University, Wuhan430062, China.
Nucleic Acids Research
|October 6, 2021
Summary
CyanoOmicsDB integrates vast cyanobacterial omics data, offering comprehensive gene functional information. This new database enhances research by providing integrated transcriptional and translational profiles for cyanobacteria.
Area of Science:
- Microbiology
- Bioinformatics
- Genomics
Background:
- Cyanobacteria are vital for research due to photosynthesis and genetic systems.
- Numerous cyanobacterial genomes are sequenced, with transcriptomic data frequently used.
- Existing omics data is underutilized and lacks comprehensive integration.
Purpose of the Study:
- To develop CyanoOmicsDB, a database for integrated cyanobacterial gene functional information.
- To provide a centralized resource for mining and analyzing extensive omics data.
Main Methods:
- Compiled data from 928 cyanobacterial genomes, including gene sequences and locations.
- Integrated transcriptional and translational profiles for model organisms like Synechocystis sp. PCC 6803.
- Incorporated data on transcriptional start sites, identified peptides, and post-translation modification sites.
Main Results:
- CyanoOmicsDB contains over 8.3 million gene entries.
- Offers detailed functional information including predicted functions, homologs, and protein domains.
- Includes specific data on transcriptional start sites, peptides, and post-translational modifications.
Conclusions:
- CyanoOmicsDB provides more comprehensive functional information than existing databases.
- Facilitates easier retrieval of functional data for cyanobacterial genes.
- A valuable resource for fundamental and biotechnological research on cyanobacteria.
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