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Advanced Near-Infrared Light for Monitoring and Modulating the Spatiotemporal Dynamics of Cell Functions in Living
Guangcun Chen1,2,3, Yuheng Cao1,2, Yanxing Tang1,2
1CAS Key Laboratory of Nano-Bio Interface Division of Nanobiomedicine and i-Lab CAS Center for Excellence in Brain Science Suzhou Institute of Nano-Tech and Nano-Bionics Chinese Academy of Sciences Suzhou 215123 China.
Near-infrared (NIR) light offers advanced optical imaging and photoregulation for deep tissue applications. This review highlights NIR techniques for monitoring and modulating cell functions in vivo, focusing on cancer, regenerative medicine, and neuroscience.
Area of Science:
- Biomedical Optics
- Photomedicine
- Cellular Dynamics
Background:
- Light-based techniques are crucial for research and clinical applications.
- Near-infrared (NIR) light (700-1700 nm) offers superior tissue penetration and lower phototoxicity compared to UV/visible light.
- NIR light enables real-time sensing and modulation of cellular events in deep tissues.
Purpose of the Study:
- To summarize recent advancements in NIR light-based techniques for monitoring and modulating cellular functions in living systems.
- To discuss the applications of NIR light in cancer theranostics, regenerative medicine, and neuroscience.
- To outline the challenges and future prospects of NIR light for cell sensing and regulation.
Main Methods:
- Review of recent scientific literature on NIR light-based imaging and photoregulation.
- Systematic introduction and discussion of applications in specific research areas.
- Analysis of current challenges and future directions.
Main Results:
- NIR light enables subcellular accuracy in monitoring and modulating deep tissue cellular events.
- Significant progress has been made in applying NIR techniques to cancer theranostics, regenerative medicine, and neuroscience.
- NIR light-based strategies offer promising avenues for in vivo biomedical applications.
Conclusions:
- NIR light-based techniques are powerful tools for in vivo cell sensing and regulation.
- Continued research and development hold significant potential for advancing biomedical applications.
- Addressing current challenges will further enhance the utility of NIR light in deep tissue studies.
