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Short-term effect of angiotensin converting enzyme inhibitor on choroidal vascularity

Emine Temel1, Nazife Aşıkgarip1, Kemal Örnek2

  • 1Kırşehir Ahi Evran Training and Research Hospital, Department of Opthalmology, Kırşehir, Turkey.

Photodiagnosis and Photodynamic Therapy
|October 6, 2021
PubMed

Insights

Angiotensin-converting enzyme (ACE) inhibitors significantly improved choroidal vascularity in hypertensive patients. This study shows ACE inhibitors enhance ocular blood flow in hypertension management.

Area of Science:

  • Ophthalmology
  • Cardiology
  • Vascular Biology

Background:

  • Hypertension is linked to microvascular changes.
  • Choroidal vascularity is a potential indicator of ocular health.
  • Angiotensin-converting enzyme (ACE) inhibitors are standard hypertension treatments.

Purpose of the Study:

  • To evaluate the impact of ACE inhibitors on choroidal vascularity.
  • To assess changes in choroidal thickness and vascularity index (CVI) in hypertensive patients.
  • To compare ocular vascular parameters before and after ACE inhibitor treatment.

Main Methods:

  • 48 treatment-naïve hypertensive patients received perindopril.
  • A control group of 48 healthy volunteers was included.
  • Enhanced-depth imaging optical coherence tomography (EDI-OCT) and binarization were used to measure choroidal parameters.

Main Results:

  • Choroidal thickness significantly increased at all measured locations post-treatment.
  • Choroidal vascularity index (CVI) and other vascular parameters showed significant improvement.
  • No significant difference in vascular parameters was observed between patients and controls at 1 month.

Conclusions:

  • ACE inhibitor treatment led to significant improvements in choroidal vascular parameters.
  • The study demonstrates a positive effect of ACE inhibitors on ocular vasculature.
  • Stromal area was the only parameter not showing significant improvement.
Abstract

Keywords:
Angiotensin-converting enzyme inhibitorsChoroidChoroidal vascularity indexOptical Coherence TomographySystemic hypertension

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