Osaka Prognostic Score Predicts In-Hospital and One-Year Mortality Following Transcatheter Aortic Valve Implantation.

Area of Science:

• Cardiology
• Biomarkers
• Prognostics

Background:

• Conventional risk models for transcatheter aortic valve implantation (TAVI) may not fully capture biological determinants of mortality.
• Inflammation, malnutrition, and immune dysfunction are critical factors influencing outcomes after TAVI.

Purpose of the Study:

• To evaluate the prognostic value of the Osaka Prognostic Score (OPS) for predicting in-hospital and one-year all-cause mortality after TAVI.
• To assess if OPS, incorporating CRP, albumin, and lymphocyte count, improves risk stratification in TAVI patients.

Main Methods:

• Retrospective analysis of 244 patients undergoing transfemoral TAVI.
• Calculation of OPS at baseline and evaluation of its association with mortality using Cox regression, ROC analysis, and restricted cubic spline modeling.

Main Results:

• In-hospital and one-year mortality rates were 11.5% and 21.7%, respectively.
• Higher OPS scores independently predicted both in-hospital (HR: 2.018) and one-year mortality (HR: 2.125).
• OPS demonstrated strong predictive accuracy (AUC 0.776 for in-hospital, 0.859 for one-year mortality) and a significant nonlinear association with mortality risk.

Conclusions:

• The Osaka Prognostic Score (OPS) is a simple, cost-effective, and biologically relevant index for predicting mortality post-TAVI.
• OPS integrates key biological markers, offering added value in risk stratification and clinical decision-making for TAVI patients.