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Published on: January 28, 2020

Aggregate Index of Systemic Inflammation as a Predictor of Acute Stent Thrombosis in STEMI Undergoing Primary PCI

Mehmet Taha Özkan1, Veysel Ozan Tanık1, Alperen Taş2

  • 1Department of Cardiology, Ankara Etlik City Hospital, Turkey.

Angiology
|June 2, 2026
PubMed

Insights

The Aggregate Index of Systemic Inflammation (AISI) can predict acute stent thrombosis and in-hospital mortality in ST-segment elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention (pPCI). This low-cost marker aids in early risk assessment.

Area of Science:

  • Cardiology
  • Inflammation Biomarkers
  • Interventional Cardiology

Background:

  • Acute stent thrombosis (ST) following primary percutaneous coronary intervention (pPCI) for ST-segment elevation myocardial infarction (STEMI) is a rare but serious complication.
  • Identifying reliable predictors of acute ST and in-hospital mortality is crucial for improving patient outcomes.
  • The Aggregate Index of Systemic Inflammation (AISI) is a novel marker derived from routine blood counts.

Purpose of the Study:

  • To evaluate the predictive value of admission AISI for acute ST in STEMI patients undergoing pPCI.
  • To assess the association between AISI and in-hospital mortality in this patient cohort.
  • To determine if AISI can serve as a rapid, low-cost risk stratification tool.

Main Methods:

  • Retrospective cohort study of 3055 STEMI patients who underwent pPCI.
  • Admission AISI calculated using the formula: (neutrophils × monocytes × platelets) / lymphocytes.
  • Multivariable logistic regression and receiver operating characteristic (ROC) analysis were employed to identify predictors and assess discrimination.

Main Results:

  • Acute ST occurred in 2.5% of patients and was associated with significantly higher in-hospital mortality (15.8% vs 3.8%).
  • Patients with acute ST had a higher admission AISI (1314.2 vs 689.7, P < .001).
  • Admission AISI independently predicted acute ST (OR 1.03) and in-hospital mortality (OR 1.05), with moderate discrimination (AUC 0.720).

Conclusions:

  • Admission AISI is an independent predictor of acute ST and early death in STEMI patients treated with pPCI.
  • The AISI demonstrates potential as a readily available and cost-effective risk stratification marker.
  • Further prospective validation is recommended to confirm the clinical utility of AISI.

Keywords:
Aggregate Index of Systemic Inflammation (AISI)ST-segment elevation myocardial infarctionacute stent thrombosisprimary percutaneous coronary interventionprognosissystemic inflammation

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