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Aspirin-induced asthma and nasal polyps
Acta Oto-Laryngologica. Supplementum
|January 1, 1986
Summary
Aspirin-induced asthma (AIA) is characterized by asthma, aspirin intolerance, and nasal polyps. Studies indicate AIA is not rare in Japan, with eosinophilia potentially aiding in understanding its pathogenesis.
Area of Science:
- Immunology
- Allergy
- Otolaryngology
Background:
- Aspirin-induced asthma (AIA) is a clinical triad involving asthma, aspirin intolerance, and nasal polyps.
- Non-steroidal anti-inflammatory drugs (NSAIDs) can trigger asthma attacks and rhinorrhea in susceptible individuals.
Purpose of the Study:
- To investigate the prevalence and characteristics of aspirin-induced asthma (AIA) in Japan.
- To explore potential etiological factors and diagnostic markers for AIA.
Main Methods:
- Retrospective analysis of 18 patients (6 males, 12 females) with NSAID-induced respiratory symptoms over several years.
- Clinical evaluation including history, physical examination, allergy testing (RAST), X-rays for sinusitis, and assessment for eosinophilia.
Main Results:
- All 18 patients experienced asthma; 13 (72.2%) had nasal polyps, often recurrent.
- Sinusitis was diagnosed in 81.8% of cases. Urticaria was present in 44.4%.
- Eosinophilia was observed in 87.5% of patients, suggesting a role in AIA pathogenesis.
Conclusions:
- Aspirin-induced asthma (AIA) is not uncommon in Japan.
- Eosinophilia may be a useful indicator for elucidating the pathogenesis of AIA and associated nasal polyps.