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Related Experiment Video

Updated: Oct 17, 2025

Evaluation of a Point-of-Care Testing Analyzer for Measuring Peripheral Blood Leukocytes
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Sustainable Laboratory-Driven Method to Decrease Repeat, Same-Day WBC Differentials at a Tertiary Care Center.

Ann Tran1, Monika Hudoba1,2, Todd Markin2

  • 1Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada.

American Journal of Clinical Pathology
|October 7, 2021
PubMed
Summary

Implementing a laboratory middleware algorithm effectively canceled repeat, same-day White Blood Cell (WBC) differentials, significantly improving laboratory resource allocation and reducing costs.

Keywords:
CBC with differentialQuality improvementTest utilization

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Area of Science:

  • Clinical Laboratory Science
  • Health Informatics
  • Healthcare Management

Background:

  • Complete Blood Count (CBC) with White Blood Cell (WBC) differential testing is frequently ordered when a CBC alone suffices.
  • Unnecessary WBC differentials contribute to increased laboratory costs and inefficient resource allocation.

Purpose of the Study:

  • To implement a laboratory middleware algorithm to automatically cancel repeat, same-day WBC differentials.
  • To achieve sustainable improvements in laboratory resource utilization and cost savings.

Main Methods:

  • A middleware algorithm was developed to identify and cancel redundant, same-day WBC differentials.
  • The algorithm was initially trialed in intensive care units before hospital-wide implementation.
  • Retrospective review of CBC with differential orders pre- and post-implementation was conducted.

Main Results:

  • The algorithm achieved a monthly cancellation rate of 5.40% for WBC differentials, totaling 10,195 cancellations.
  • An estimated $0.99 CAD in savings per canceled differential and 1,060 minutes of technologist time were realized.
  • Over 99.9% of canceled differentials remained canceled, with minimal patient impact.

Conclusions:

  • A middleware algorithm offers a simple and sustainable solution for optimizing laboratory utilization.
  • Automated cancellation of repeat WBC differentials leads to significant cost savings and improved efficiency.
  • This approach demonstrates lasting improvements in laboratory resource management.