Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Mood Altering Waters: Multidimensional Profiling and Chiral Characterization of Antidepressants in Effluent-Impacted Waterways.

Environmental science & technology·2026

Same author

Effects of environmental variables on phycotoxin degradation and preliminary identification of transformation products.

Water research·2026

Same author

Atmospheric Dispersal and Local Drivers Shape Snow and Air Microbial Communities in the Western Antarctic Peninsula.

Environmental microbiology·2026

Same author

Mapping the human chemical exposome for public health.

Nature medicine·2026

Same author

Validating Direct Mass Spectrometry Screening for Grease-Proofers Containing 6:2 Fluorotelomer Alcohol in Fiber-Based Food Packaging.

Journal of agricultural and food chemistry·2026

Same author

High-Resolution LC-MS Characterization of <i>Ramaria flavobrunnescens,</i> a Coral Mushroom Toxic to Livestock, Reveals Fungal, Bacterial, and Eucalyptus Tree Metabolites.

Toxins·2026

Search research articles

Related Experiment Video

Updated: Oct 17, 2025

Improving Reproducibility to Meet Minimal Information for Studies of Extracellular Vesicles 2018 Guidelines in Nanoparticle Tracking Analysis

Improving Reproducibility to Meet Minimal Information for Studies of Extracellular Vesicles 2018 Guidelines in Nanoparticle Tracking Analysis

Published on: November 17, 2021

Nontargeted Analysis Study Reporting Tool: A Framework to Improve Research Transparency and Reproducibility.

Katherine T Peter¹, Allison L Phillips², Ann M Knolhoff³

¹U.S. National Institute of Standards and Technology, 331 Fort Johnson Road, Charleston, South Carolina 29412, United States.

Analytical Chemistry

|October 7, 2021

Summary

This summary is machine-generated.

Non-targeted analysis (NTA) lacks reporting standards, hindering scientific transparency. A new NTA Study Reporting Tool (SRT) provides a framework to improve study design and standardize reporting for mass spectrometry workflows.

More Related Videos

Using Human Differentially Expressed Gene Lists to Perform Downstream Pathway Enrichment Analysis and Target Prioritization

Using Human Differentially Expressed Gene Lists to Perform Downstream Pathway Enrichment Analysis and Target Prioritization

Published on: October 3, 2025

An Analytical Tool-box for Comprehensive Biochemical, Structural and Transcriptome Evaluation of Oral Biofilms Mediated by Mutans Streptococci

An Analytical Tool-box for Comprehensive Biochemical, Structural and Transcriptome Evaluation of Oral Biofilms Mediated by Mutans Streptococci

Published on: January 25, 2011

Related Experiment Videos

Last Updated: Oct 17, 2025

Improving Reproducibility to Meet Minimal Information for Studies of Extracellular Vesicles 2018 Guidelines in Nanoparticle Tracking Analysis

Improving Reproducibility to Meet Minimal Information for Studies of Extracellular Vesicles 2018 Guidelines in Nanoparticle Tracking Analysis

Published on: November 17, 2021

Using Human Differentially Expressed Gene Lists to Perform Downstream Pathway Enrichment Analysis and Target Prioritization

Using Human Differentially Expressed Gene Lists to Perform Downstream Pathway Enrichment Analysis and Target Prioritization

Published on: October 3, 2025

An Analytical Tool-box for Comprehensive Biochemical, Structural and Transcriptome Evaluation of Oral Biofilms Mediated by Mutans Streptococci

An Analytical Tool-box for Comprehensive Biochemical, Structural and Transcriptome Evaluation of Oral Biofilms Mediated by Mutans Streptococci

Published on: January 25, 2011

Area of Science:

Analytical Chemistry
Metabolomics
Exposomics

Background:

Non-targeted analysis (NTA) using mass spectrometry is increasingly utilized across diverse scientific fields.
Existing reporting guidelines for NTA are insufficient, compromising scientific transparency and reproducibility.
Lack of standardized reporting impedes robust study design and peer review processes.

Purpose of the Study:

To develop an interdisciplinary framework, the NTA Study Reporting Tool (SRT), for comprehensive NTA methods and results reporting.
To assess the SRT's validity and utility in guiding study design and evaluating reporting quality.

Main Methods:

The NTA Study Reporting Tool (SRT) was developed as an easy-to-use framework.
Eleven NTA practitioners evaluated eight published articles from environmental, food, and health exposomic studies using the SRT.
Participant scores were compared to assess the tool's effectiveness.

Main Results:

The SRT demonstrated validity in structuring study design and manuscript writing for NTA.
Author self-assigned scores using the SRT aligned with peer reviewer scores, indicating its utility for self-evaluation.
Key areas needing improvement in NTA reporting were identified, including analytical sequence and quality assurance/quality control.

Conclusions:

The NTA Study Reporting Tool (SRT) offers a structured approach to enhance NTA reporting quality.
Widespread adoption of the SRT can lead to improved study design and standardized reporting practices.
Implementation of the SRT is expected to increase the broader use and acceptance of NTA data in scientific research.