Related Experiment Video
Updated: Oct 17, 2025
06:51
Multilevel Microdissection and Functional-Structural Profiling of Human Renal Arterial Branches
Published on: September 5, 2025
175
Renal Artery Variations in Patients With Mild-to-Moderate Hypertension From the RADIANCE-HTN SOLO Trial.
Kintur Sanghvi1, Yale Wang2, Joost Daemen3
1Deborah Heart & Lung Center, Brown Mills, NJ, USA.
Summary
Renal artery anatomy varies significantly, with many patients having accessory arteries. Pre-procedure imaging like CTA/MRA is crucial for assessing renal artery anatomy and pathology before renal denervation.
Area of Science:
- Cardiovascular Imaging
- Interventional Cardiology
- Hypertension Management
Background:
- The RADIANCE-HTN SOLO trial investigated ultrasound-based renal denervation (RDN) for mild-to-moderate hypertension.
- This trial involved patients treated while not on antihypertensive medications.
Purpose of the Study:
- To evaluate the diversity of renal artery (RA) anatomy.
- To identify the prevalence of RA pathology in patients within the RADIANCE-HTN SOLO trial.
Main Methods:
- Utilized pre-randomization CT- or MR-angiography (CTA, MRA) for 324 patients.
- Independent review assessed RA anatomy and vascular pathology for suitability for RDN.
Main Results:
- 178 patients had simple RA anatomy; 27 (8.3%) had dual RAs; 40% had accessory RAs.
- Incidental findings included RA stenosis (2.8%), fibromuscular dysplasia (2.8%), and tumors (0.6%).
Conclusions:
- Pre-procedure CTA/MRA is vital for assessing variable RA anatomy before RDN.
- Imaging can detect RA lesions and tumors requiring further evaluation before RDN consideration.
Related Concept Videos
01:30Hypertension III: Clinical Manifestations and Diagnostic Studies
105
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
105
01:25Antihypertensive Drugs: Direct Renin Inhibitors
911
The renin-angiotensin-aldosterone system (RAAS) is an intricate physiological pathway involving numerous enzymes and hormones, including renin, angiotensin-converting enzyme (ACE), angiotensin I and II, and aldosterone. Imbalances within this system increase the production of angiotensin II and aldosterone. Increased angiotensin II levels promote vasoconstriction and blood pressure elevation. Concurrently, higher aldosterone levels stimulate sodium and water reabsorption in the kidneys,...
911
01:18Hypertension and Regulation of Blood Pressure
3.3K
Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
3.3K
01:30Antihypertensive Drugs: Angiotensin II Receptor Blockers
1.8K
In the renin-angiotensin-aldosterone system, a hormone called angiotensin II plays a crucial role. It binds to the AT1 receptors in vascular smooth muscles coupled with Gq proteins. The activation of these receptors activates an enzyme called phospholipase C, which releases two molecules: inositol trisphosphate and diacylglycerol. These molecules cause a chain reaction that leads to the phosphorylation of myosin light chains and promotes interaction between actin and myosin, leading to smooth...
1.8K
01:30Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors
1.7K
Angiotensin-converting enzyme (ACE), a vital component of the renin-angiotensin-aldosterone system, is abundant in lung endothelial cells. ACE converts the inactive decapeptide, angiotensin I, into the active octapeptide, angiotensin II. This potent vasoconstrictor narrows blood vessels, increasing resistance to blood flow and elevating blood pressure. Angiotensin II also stimulates aldosterone production, encouraging kidney cells to reabsorb more sodium and water from urine, thereby increasing...
1.7K
01:29Hypertension II: Pathophysiology
176
Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
176