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Opioid Prescribing Patterns for Ulcerative Keratitis.

Alexa R Thibodeau1, Leslie M Niziol1, Bradford L Tannen1

  • 1Department of Ophthalmology and Visual Sciences, W.K. Kellogg Eye Center, University of Michigan, Ann Arbor, MI; and.

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PubMed
Summary
This summary is machine-generated.

Opioid prescription rates for ulcerative keratitis vary by cause. Acanthamoeba, fungal, and polymicrobial keratitis had higher opioid use than bacterial or viral types. Pain management may need tailoring to keratitis etiology.

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Area of Science:

  • Ophthalmology
  • Pharmacology

Background:

  • Ulcerative keratitis is a serious eye condition requiring prompt management.
  • Pain is a significant symptom associated with ulcerative keratitis.
  • Opioid analgesics are sometimes prescribed for pain management in ocular conditions.

Purpose of the Study:

  • To characterize and compare opioid prescription rates across different etiologic types of ulcerative keratitis.
  • To investigate variations in opioid use based on the underlying cause of ulcerative keratitis.

Main Methods:

  • A retrospective cohort study analyzed electronic health record data from September 1, 2014, to December 22, 2020.
  • Ulcerative keratitis cases were categorized by etiology (bacterial, fungal, viral, acanthamoeba, inflammatory, polymicrobial, unspecified) using a rule-based classification system.
  • Opioid prescriptions were quantified in morphine milligram equivalents (MME) within 90 days of diagnosis and compared between keratitis types.

Main Results:

  • Of 3322 patients, 5.2% received opioid prescriptions within 90 days of diagnosis.
  • Opioid prescription rates were significantly higher for acanthamoeba (32.4%), fungal (21.1%), and polymicrobial (25.0%) keratitis compared to bacterial (6.7%), unspecified (2.9%), or viral (1.8%) types (P < 0.05).
  • The total quantity of opioids prescribed within 90 days did not differ significantly between keratitis types (P = 0.6559).

Conclusions:

  • The etiology of ulcerative keratitis appears to influence the likelihood of receiving an opioid prescription.
  • Findings suggest a need for improved pain assessment and the development of tailored pain management strategies for patients with different types of ulcerative keratitis.