Related Experiment Video

Updated: Oct 17, 2025

Author Spotlight: Collecting the Brain and Serum from the Same Mice Fetus to Study Brain Tumor Development
05:44

Author Spotlight: Collecting the Brain and Serum from the Same Mice Fetus to Study Brain Tumor Development

Published on: May 17, 2024

774

Association of Attention Deficit/Hyperactivity Disorder With Events Occurring During Pregnancy and Perinatal Period

Jianbo Liu1, Yuqiong He2,3, Yanmei Shen2,3

  • 1Department of Child Psychiatry of Shenzhen Kangning Hospital, Shenzhen Mental Health Center, School of Mental Health, Shenzhen University, Shenzhen, China.

Frontiers in Psychology
|October 8, 2021
PubMed

Insights

Pregnancy and perinatal complications like threatened abortion and neonatal asphyxia are linked to attention deficit/hyperactivity disorder (ADHD). Specific factors like instrumental delivery and low birth weight also pose risks for ADHD in certain subgroups.

Area of Science:

  • Neuroscience
  • Developmental Pediatrics
  • Child Psychiatry

Background:

  • The connection between prenatal and perinatal events and the development of attention deficit/hyperactivity disorder (ADHD) remains incompletely understood.
  • Investigating these early-life factors is crucial for understanding ADHD etiology.

Purpose of the Study:

  • To investigate the association between pregnancy and perinatal events and the occurrence of ADHD.
  • To identify specific risk factors during pregnancy and childbirth that may contribute to ADHD development.

Main Methods:

  • A two-phase cross-sectional study involving 3,418 students from 13 schools.
  • Utilized the Child Behavior Checklist (CBCL) for initial screening.
  • Employed the Mini International Neuropsychiatric Interview for Children and Adolescents (MINI-KID) and DSM-IV criteria for diagnosis.

Main Results:

  • Threatened abortion (TA) and neonatal asphyxia (NA) were positively associated with ADHD.
  • TA was a risk factor for ADHD without comorbidity.
  • Instrumental delivery and NA were risk factors for ADHD with comorbidity.
  • TA and NA were risk factors for ADHD in males; low birth weight (LBW) was a risk factor in females.

Conclusions:

  • Threatened abortion is a risk factor for ADHD without comorbid conditions.
  • Instrumental delivery and neonatal asphyxia are risk factors for ADHD with comorbid conditions.
  • Specific perinatal factors like TA, NA, and LBW are significant risk factors for ADHD, with variations observed between sexes and comorbidity status.

Keywords:
ADHDinstrumental deliverylow birth weightneonatal asphyxiathreatened abortion

More Related Videos

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale19:15

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Published on: August 25, 2014

86.7K
Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants06:39

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants

Published on: June 13, 2021

3.2K

Related Concept Videos

Attention-Deficit/Hyperactivity Disorder01:30

Attention-Deficit/Hyperactivity Disorder

Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
429
Autism Spectrum Disorder01:19

Autism Spectrum Disorder

Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
485
Teratogenicity01:07

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
3.0K
Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
823
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
2.1K