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Updated: Oct 17, 2025

Ex Vivo Expansion of Hematopoietic Stem Cells from Human Umbilical Cord Blood-derived CD34+ Cells Using Valproic Acid
Published on: April 11, 2019
COVID-19 Pandemic Impact on Cord Blood Collection for Stem Cell Use and Actual Perspectives
Natalia Turcan1, Bogdan Ivanescu2, Felician Stancioiu3
1Department of Obstetrics and Gynecology, Emergency University Hospital, Bucharest, Romania.
Insights
Collecting cord blood for stem cell storage offers therapeutic potential for various diseases. This procedure can also assess maternal COVID-19 antibody transfer, informing consent for expectant parents.
Area of Science:
- Reproductive Medicine
- Immunology
- Hematology
Background:
- Umbilical cord stem cells show therapeutic promise for bone, neurological, metabolic, and genetic diseases.
- Cord blood collection quality depends on maternal and fetal factors, requiring individualized strategies.
- The COVID-19 pandemic highlighted the need for enhanced cord blood collection protocols.
Abstract:
Cord blood collection for stem cell storage remains a popular procedure due to the advantages associated to it. In the last ten years, the therapeutic potential of umbilical cord stem cells was demonstrated in the treatment of bone pathologies, neuropsychiatry, metabolic and genetic diseases. There are several factors with direct influence on the quality and quantity of cord blood collection for stem cell storage. The collection principles should be individualized according to the maternal and fetal characteristics. Furthermore, in the context of COVID-19 pandemic, additional information can be obtained through this procedure. We present a specific case-adapted strategy for the collection of umbilical cord blood and its application in analyzing the transplacental transfer of maternal COVID-19 antibodies after vaccination. We suggest that the informed consent offered to the future parents prior to the procedure should include the history of COVID-19 during pregnancy, the vaccination status of the mother and the gestational age at the time when this event occurred.
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