Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Novel aptamers targeting heparan sulfate for delivery of RNA therapeutics in Alzheimer's disease.

Progress in biomedical engineering (Bristol, England)·2026
Same author

Identification of a Novel Disulfidptosis-Related Five-Gene Signature for Prognostic Prediction and Immune Characterization in Esophageal Cancer.

Biology·2026
Same author

SBM-Attention U-Net: A Hybrid Transformer Network for Liver Tumor Segmentation in Medical Images.

Sensors (Basel, Switzerland)·2026
Same author

Nanomaterial Engineered Biosensors and Stimulus-Responsive Platform for Emergency Monitoring and Intelligent Diagnosis.

Biosensors·2025
Same author

Hybrid nanomaterials-based biomedical phototheranostic platforms.

Progress in biomedical engineering (Bristol, England)·2025
Same author

Advances in engineered exosomes towards cancer diagnosis and therapeutics.

Progress in biomedical engineering (Bristol, England)·2025

Related Experiment Video

Updated: Oct 17, 2025

Exploring Sequence Space to Identify Binding Sites for Regulatory RNA-Binding Proteins
11:34

Exploring Sequence Space to Identify Binding Sites for Regulatory RNA-Binding Proteins

Published on: August 9, 2019

6.8K

Engineered Aptamer-Organic Amphiphile Self-Assemblies for Biomedical Applications: Progress and Challenges.

Hongjie Xiong1, Liu Liu1, Yihan Wang1

  • 1State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, China.

Small (Weinheim an Der Bergstrasse, Germany)
|October 8, 2021
PubMed
Summary

Nucleic acid aptamers form self-assemblies (AOASs) for advanced biomedical applications like drug delivery and imaging. These aptamer-organic amphiphile self-assemblies offer enhanced targeting and customizable structures for improved therapeutic outcomes.

Keywords:
amphiphile self-assemblyaptamersbiomedical applicationmorphology controlsynthesis

More Related Videos

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid
10:42

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid

Published on: February 27, 2019

9.5K
Aptamer-Based Target Detection Facilitated by a 3-Stage G-Quadruplex Isothermal Exponential Amplification Reaction
03:38

Aptamer-Based Target Detection Facilitated by a 3-Stage G-Quadruplex Isothermal Exponential Amplification Reaction

Published on: October 6, 2022

1.6K

Related Experiment Videos

Last Updated: Oct 17, 2025

Exploring Sequence Space to Identify Binding Sites for Regulatory RNA-Binding Proteins
11:34

Exploring Sequence Space to Identify Binding Sites for Regulatory RNA-Binding Proteins

Published on: August 9, 2019

6.8K
A Tripeptide-Stabilized Nanoemulsion of Oleic Acid
10:42

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid

Published on: February 27, 2019

9.5K
Aptamer-Based Target Detection Facilitated by a 3-Stage G-Quadruplex Isothermal Exponential Amplification Reaction
03:38

Aptamer-Based Target Detection Facilitated by a 3-Stage G-Quadruplex Isothermal Exponential Amplification Reaction

Published on: October 6, 2022

1.6K

Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Molecular Biology

Background:

  • Nucleic acid aptamers are versatile targeting ligands in biomedicine due to specificity and low immunogenicity.
  • Aptamers can be chemically modified to form aptamer-organic amphiphiles (AOAs) that self-assemble into aptamer-organic amphiphile self-assemblies (AOASs).
  • AOASs offer enhanced target binding, nuclease resistance, and cargo loading capabilities for various bioapplications.

Purpose of the Study:

  • To review the synthesis of oligonucleotide-organic amphiphiles.
  • To systematically review recent progress in different types of AOASs for bioapplications.
  • To discuss strategies for AOAS morphology control and future perspectives.

Main Methods:

  • Summarization of general synthesis methods for oligonucleotide-organic amphiphiles.
  • Review of recent advancements in aptamer-polymer, aptamer-lipid, and aptamer-cell self-assemblies.
  • Analysis of morphology control strategies for AOASs.

Main Results:

  • AOASs demonstrate significant potential in targeted drug delivery, cancer therapy, biosensing, and bioimaging.
  • Morphology manipulation of AOASs enables tailored biomedical functions.
  • Stimuli-responsive AOASs facilitate site-specific drug release and enhanced tumor penetration.

Conclusions:

  • Aptamer-organic amphiphile self-assemblies represent a powerful platform for advanced biomedical applications.
  • Controlling the morphology of AOASs is crucial for optimizing their functions.
  • Further research into AOASs holds promise for innovative therapeutic and diagnostic strategies.