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Updated: Oct 17, 2025

DNA Sequence Recognition by DNA Primase Using High-Throughput Primase Profiling
Published on: October 8, 2019
Unveiling the boost in the sandwich priming technique
María Fernández-López1, Colin J Davis2, Manuel Perea1,3
1Universitat de València, València, Spain.
Abstract:
The masked priming technique (which compares #####-house-HOUSE vs. #####-fight-HOUSE) is the gold-standard tool to examine the initial moments of word processing. Lupker and Davis showed that adding a pre-prime identical to the target produced greater priming effects in the sandwich technique (which compares #####-HOUSE-house-HOUSE vs #####-HOUSE-fight-HOUSE). While there is consensus that the sandwich technique magnifies the size of priming effects relative to the standard procedure, the mechanisms underlying this boost are not well understood (i.e., does it reflect quantitative or qualitative changes?). To fully characterise the sandwich technique, we compared the sandwich and standard techniques by examining the response times (RTs) and their distributional features (delta plots; conditional-accuracy functions), comparing identity versus unrelated primes. The results showed that the locus of the boost in the sandwich technique was two-fold: faster responses in the identity condition (via a shift in the RT distributions) and slower responses in the unrelated condition. We discuss the theoretical and methodological implications of these findings.
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