Multifunctional Nanosystems with Enhanced Cellular Uptake for Tumor Therapy.

Area of Science:

• Biomedicine
• Nanotechnology
• Oncology

Background:

• Nanotechnology offers advanced strategies for cancer therapy.
• Cellular uptake of nanosystems is crucial for therapeutic effectiveness.

Purpose of the Study:

• To systematically review recent advancements in improving nanosystem cellular uptake for cancer treatment.
• To provide a comprehensive overview of strategies enhancing drug delivery and therapeutic outcomes.

Main Methods:

• Classification of nanosystem uptake enhancement strategies into three categories: extracellular microenvironment stimulation, active targeting for cellular internalization, and subcellular localization for intracellular retention.
• Analysis of major factors influencing nanosystem delivery for developing multifunctional systems.

Main Results:

• Strategies focus on enhancing tumor cell accumulation, permeation, and internalization.
• Multifunctional nanosystems can be developed by utilizing key delivery factors.
• Subcellular localization improves intracellular retention of therapeutics.

Conclusions:

• Optimizing nanosystem cellular uptake is key to advancing cancer therapy.
• This review offers insights and strategies for developing novel anticancer nanosystems for clinical application.