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Published on: September 19, 2019
Application of microfluidic chips in anticancer drug screening
Xin-Yue Fan1, Zhuo-Fen Deng1, Yan-Yan Yan2
1Key Laboratory of Molecular Target and Clinical Pharmacology and the State and NMPA Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Microfluidic chips offer rapid, efficient, and high-throughput drug screening. This technology is advancing drug discovery, particularly for natural product anticancer drugs, by integrating various screening aspects on a single platform.
Area of Science:
- Biotechnology
- Drug Discovery
- Microfluidics
Background:
- Drug screening technologies are rapidly advancing, driving efficiency and throughput.
- Microfluidics is emerging as a key innovative technology in drug discovery.
- Microfluidic chip technology offers novel approaches for drug screening.
Purpose of the Study:
- To review recent progress in microfluidic chip technology for drug screening.
- To summarize microfluidic chip screening platforms based on structure, sample handling, cell culture, and detection.
- To discuss applications and future prospects, especially for natural product anticancer drugs.
Main Methods:
- Review of recent literature on microfluidic chip technology in drug screening.
- Analysis of microfluidic chip components: structure, sample injection, cell culture, and detection.
- Discussion of applications in screening natural product anticancer drugs.
Main Results:
- Microfluidic chips integrate multiple functions for enhanced drug screening.
- Key aspects of microfluidic platforms include chip design, sample handling, cell culture, and detection.
- The technology shows promise for screening natural product anticancer drugs based on various properties.
Conclusions:
- Microfluidic chips are a significant advancement in drug screening, enabling rapid and efficient discovery.
- The integration of diverse functionalities on-chip optimizes the screening process.
- Future applications include the targeted screening of natural product anticancer drugs.
