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[Removal of Shield Needles from Graphene Oxide Thrombus and Preparation]
Yuting Yang1, Yuanjian Zhong1, Lichun Zhao1
1Guangxi University of Chinese Medicine, Nanning, 530200.
Insights
This study introduces a novel graphene oxide shield needle for precise thrombus removal. This device offers multi-angle rotation, targeted drug delivery, and adsorption of small clots to prevent embolization, enhancing thrombotherapy safety and efficacy.
Area of Science:
- Biomedical Engineering
- Materials Science
- Cardiovascular Medicine
Background:
- Atherosclerosis is a chronic inflammatory vascular disease leading to thrombosis and severe health risks.
- Current thrombotherapy methods face challenges including vascular damage, infection, and secondary embolization.
Purpose of the Study:
- To develop and prepare a graphene oxide shield needle for effective and safe thrombus removal.
- To evaluate the advantages of the novel device in precise grinding, drug delivery, and emboli prevention.
Main Methods:
- Design and fabrication of a graphene oxide shield needle with components like a rotating shaft, adsorption pipe, and integrated camera.
- Utilizing multi-angle rotation for precise thrombus grinding.
- Incorporating thrombolytic drug delivery and a graphene oxide coating for infection protection.
Main Results:
- The device enables precise, multi-angle rotation grinding of thrombi, minimizing vascular damage.
- Thrombolytic drugs can be administered during grinding, and small thrombi are adsorbed to prevent secondary embolization.
- A graphene oxide coating on the needle provides antibacterial and infection-protective properties.
Conclusions:
- The developed graphene oxide shield needle offers a safe and effective approach to thrombotherapy.
- This innovation holds significant potential for advancing the treatment of atherosclerosis and related vascular diseases.
- The study highlights the practical value of graphene applications in medical interventions.
Abstract:
Atherosclerosis is a chronic inflammatory disease commonly seen in clinical practice. It can lead to thickening of vascular intima, occlusion of lumen stenosis and thrombosis, leading to angina pectoris, hypertension, myocardial infarction and other diseases, posing a serious threat to human life and health. This study provides a method for removing shield needles from graphene oxide thrombus and its preparation. The graphene oxide shield needle mainly includes flexible rotating shaft, radial flexible rod, rotating needle, adsorption main pipe and dosing main pipe, laser measuring device, high definition camera and other structures, which has the following advantages:firstly, it achieves multi-angle rotation grinding thrombosis, precise rotation grinding, avoids vascular damage and infection; secondly, thrombolytic drugs can be applied in the process of rotary grinding and small thrombus can be adsorbed to effectively avoid secondary embolization of blood vessels; thirdly, it a coating of graphene oxide on a rotating needle, which protects against bacteria and infection. This study has practical reference value for the development of thrombotherapy and the application of graphene in the medical field.
