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Circulating CD5L is associated with cardiovascular events and all-cause mortality in individuals with chronic kidney

Esmeralda Castelblanco1,2,3, Maria R Sarrias4, Àngels Betriu5

  • 1Department of Endocrinology and Nutrition, Hospital de la Santa Creu i Sant Pau and Sant Pau Biomedical Research Institute (IIB Sant Pau), Barcelona 08041, Spain.

Aging
|October 11, 2021
PubMed

Insights

Higher CD5L levels increase cardiovascular event and mortality risk in chronic kidney disease (CKD) patients. Soluble CD36 (sCD36) showed no significant association with these adverse outcomes.

Area of Science:

  • Nephrology
  • Cardiology
  • Biomarkers

Background:

  • Cardiovascular disease (CVD) is a leading cause of mortality in patients with chronic kidney disease (CKD).
  • Identifying novel biomarkers for cardiovascular event (CVE) risk stratification in CKD is crucial.

Purpose of the Study:

  • To investigate the association of CD5L and soluble CD36 (sCD36) with the risk of CVE and all-cause mortality in individuals with CKD.

Main Methods:

  • Prospective cohort study of 1,516 participants with CKD, free from pre-existing CVD.
  • Cox proportional hazards regression was used to analyze the association of baseline CD5L and sCD36 with a composite CVE endpoint and all-cause mortality, adjusted for established CV risk factors.
  • Follow-up duration was 4 years.

Main Results:

  • Higher baseline CD5L concentrations were significantly associated with an increased risk of CVE (HR: 1.17, 95% CI: 1.0-1.36) and all-cause mortality (HR: 1.22, 95% CI: 1.01-1.48) after multivariable adjustment.
  • No significant association was found between sCD36 levels and adverse cardiovascular outcomes or mortality.
  • The study included 98 CVEs and 72 deaths (26 CV-related) over 4 years.

Conclusions:

  • Elevated CD5L concentrations represent a novel, independent risk factor for future cardiovascular events and all-cause mortality in individuals with CKD.
  • CD5L may serve as a potential biomarker for risk prediction in this high-risk population.
  • sCD36 does not appear to be associated with cardiovascular risk in CKD.

Keywords:
CD5Lcardiovascular eventschronic kidney diseasemortalitysCD36

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