Liver disorders in COVID-19, nutritional approaches and the use of phytochemicals

Nancy Vargas-Mendoza1, Jazmín García-Machorro1, Marcelo Angeles-Valencia1

  • 1Laboratorio de Medicina de Conservacion, Instituto Politécnico Nacional, México 11340, Mexico.

Insights

This review discusses malnutrition in COVID-19 patients, focusing on nutritional strategies for managing the disease and liver injury. It also explores phytochemicals for prevention and treatment.

Area of Science:

  • Immunology
  • Virology
  • Nutrition Science

Background:

  • Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, has led to a global pandemic.
  • The virus triggers a hyperinflammatory response, cytokine storm, and oxidative stress, causing respiratory, gastrointestinal, and liver symptoms.
  • Malnutrition is prevalent in COVID-19 patients, exacerbating poor outcomes and mortality.

Purpose of the Study:

  • To review strategies for identifying malnutrition in COVID-19 patients.
  • To establish nutritional approaches for managing COVID-19 and associated liver injury.
  • To consider the role of phytochemicals in COVID-19 prevention and treatment.

Main Methods:

  • Literature review of studies on COVID-19, malnutrition, and liver injury.
  • Analysis of nutritional requirements and their impact on immune response.
  • Exploration of phytochemicals as potential therapeutic agents.

Main Results:

  • Identified key nutritional challenges and strategies for COVID-19 patients.
  • Highlighted the link between malnutrition, immune response, and disease severity.
  • Discussed the potential of phytochemicals in managing COVID-19 and liver injury.

Conclusions:

  • Nutritional management is crucial for improving outcomes in COVID-19 patients with liver injury.
  • Phytochemicals show promise for COVID-19 prevention and treatment.
  • Integrated nutritional and therapeutic strategies are essential for comprehensive patient care.

Related Concept Videos

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
26
Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
1.4K
Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow01:26

Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow

Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug...
26
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
454
Liver Physiology01:30

Liver Physiology

The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of  70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
2.0K
Liver Regeneration01:24

Liver Regeneration

The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
3.5K