Related Experiment Video
Updated: Oct 17, 2025

Investigating the Protective Effects of Platycodin D on Non-Alcoholic Fatty Liver Disease in a Palmitic Acid-Induced In Vitro Model
Published on: December 2, 2022
Liver disorders in COVID-19, nutritional approaches and the use of phytochemicals
Nancy Vargas-Mendoza1, Jazmín García-Machorro1, Marcelo Angeles-Valencia1
1Laboratorio de Medicina de Conservacion, Instituto Politécnico Nacional, México 11340, Mexico.
Insights
This review discusses malnutrition in COVID-19 patients, focusing on nutritional strategies for managing the disease and liver injury. It also explores phytochemicals for prevention and treatment.
Area of Science:
- Immunology
- Virology
- Nutrition Science
Background:
- Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, has led to a global pandemic.
- The virus triggers a hyperinflammatory response, cytokine storm, and oxidative stress, causing respiratory, gastrointestinal, and liver symptoms.
- Malnutrition is prevalent in COVID-19 patients, exacerbating poor outcomes and mortality.
Purpose of the Study:
- To review strategies for identifying malnutrition in COVID-19 patients.
- To establish nutritional approaches for managing COVID-19 and associated liver injury.
- To consider the role of phytochemicals in COVID-19 prevention and treatment.
Main Methods:
- Literature review of studies on COVID-19, malnutrition, and liver injury.
- Analysis of nutritional requirements and their impact on immune response.
- Exploration of phytochemicals as potential therapeutic agents.
Main Results:
- Identified key nutritional challenges and strategies for COVID-19 patients.
- Highlighted the link between malnutrition, immune response, and disease severity.
- Discussed the potential of phytochemicals in managing COVID-19 and liver injury.
Conclusions:
- Nutritional management is crucial for improving outcomes in COVID-19 patients with liver injury.
- Phytochemicals show promise for COVID-19 prevention and treatment.
- Integrated nutritional and therapeutic strategies are essential for comprehensive patient care.
Abstract:
Coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), has affected millions of people globally. It was declared a pandemic by the World Health Organization in March 2020. The hyperinflammatory response to the entry of SARS-CoV-2 into the host through angiotensin-converting enzyme 2 is the result of a "cytokine storm" and the high oxidative stress responsible for the associated symptomatology. Not only respiratory symptoms are reported, but gastrointestinal symptoms (diarrhea, vomiting, and nausea) and liver abnormalities (high levels of aspartate aminotransferase, alanine aminotransferase transaminases, and bilirubin) are observed in at least 30% of patients. Reduced food intake and a delay in medical services may lead to malnutrition, which increases mortality and poor outcomes. This review provides some strategies to identify malnutrition and establishes nutritional approaches for the management of COVID-19 and liver injury, taking energy and nutrient requirements and their impact on the immune response into account. The roles of certain phytochemicals in the prevention of the disease or as promising target drugs in the treatment of this disease are also considered.
More Related Videos
07:03Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss
Published on: July 19, 2024
08:41Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease
Published on: March 24, 2023
Related Concept Videos
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test
Diseases of the Liver and Gallbladder
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Liver Physiology
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
Liver Regeneration
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...