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Relationship between nonalcoholic fatty liver disease and chronic kidney disease could start in childhood

Anna Di Sessa1, Stefano Guarino1, Rosa Melone1

  • 1Department of Woman, Child, and General and Specialized Surgery, University of Campania Luigi Vanvitelli, Naples 80138, Italy.

World Journal of Gastroenterology
|October 11, 2021
PubMed

Insights

Nonalcoholic fatty liver disease (NAFLD) may be an early risk factor for chronic kidney disease (CKD) in children. Understanding this link is crucial due to shared cardiometabolic risks.

Area of Science:

  • Pediatric Nephrology
  • Hepatology
  • Metabolic Disorders

Background:

  • Nonalcoholic fatty liver disease (NAFLD) and chronic kidney disease (CKD) are increasingly recognized in adults.
  • Emerging evidence suggests a similar association in pediatric populations.
  • Both conditions are linked to significant cardiovascular and metabolic disease risks.

Purpose of the Study:

  • To investigate the association between NAFLD and CKD in children.
  • To explore NAFLD as a potential early risk factor for CKD development.
  • To understand the implications for cardiometabolic risk in affected children.

Main Methods:

  • Review of published studies on NAFLD and CKD in pediatric populations.
  • Analysis of potential genetic influences (NAFLD risk polymorphisms).
  • Assessment of shared risk factors and disease progression.

Main Results:

  • Growing scientific interest in the NAFLD-CKD link in children.
  • Studies suggest NAFLD may precede or contribute to CKD.
  • NAFLD risk polymorphisms may exacerbate cardiovascular and metabolic risks.

Conclusions:

  • The relationship between NAFLD and CKD in childhood warrants further investigation.
  • Early identification and management of NAFLD may be important for preventing pediatric CKD.
  • Addressing shared cardiometabolic risk factors is essential for both conditions.

Keywords:
ChildrenChronic kidney diseaseLiverNonalcoholic fatty liver disease

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