Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Open and closed-loop control systems01:17

Open and closed-loop control systems

1.1K
Control systems are foundational elements in automation and engineering. They are broadly categorized into open-loop and closed-loop systems. These classifications hinge on the presence or absence of feedback mechanisms, significantly influencing the system's performance, complexity, and application.
An open-loop control system operates without feedback from the output. It consists of two primary elements: the controller and the controlled process. The controller receives an input signal...
1.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Time-resolved single-nucleus profiling of inter- and intracellular signaling in optic nerve injury: From the hyperacute phase to the acute phase.

Neural regeneration research·2026
Same author

Rhein antagonizes glucocorticoid receptor signaling to activate SIRT1-dependent thermogenesis in brown adipose tissue and ameliorate obesity.

Phytomedicine : international journal of phytotherapy and phytopharmacology·2026
Same author

Ion-imprinted covalent organic framework/PVDF mixed matrix membrane: Preparation, selective removal of Cr(VI) and its adsorption behavior.

Journal of environmental sciences (China)·2026
Same author

Common Electrophysiology Biomarkers Collected at Home Robustly Track Depression Recovery With Deep Brain Stimulation.

medRxiv : the preprint server for health sciences·2026
Same author

ZFP36L1 Enhances Microglial Ferroptosis in Ischemic Stroke by Reducing FTO-Mediated N6-Methyladenosine Demethylation of ACSL1 mRNA.

The Kaohsiung journal of medical sciences·2026
Same author

Targeted Molecular Profiling of Circulating Cell-Free DNA in Patients With Gastroesophageal Adenocarcinoma.

JCO precision oncology·2026
Same journal

A Multi-Head Attention Transformer Model for Wearable in Situ Fall Detection.

IEEE access : practical innovations, open solutions·2026
Same journal

Validating Single-Camera Pose Estimation Against Multi-Camera Motion Capture for Accessible Biomechanical Assessment.

IEEE access : practical innovations, open solutions·2026
Same journal

Learning to Diagnose Privately: DP-Powered LLMs for Radiology Report Classification.

IEEE access : practical innovations, open solutions·2026
Same journal

Radio-Frequency Toroid Susceptometry of Magnetic Nanoparticles: What Goes Around Comes Around.

IEEE access : practical innovations, open solutions·2026
Same journal

Cross-Architecture Knowledge Distillation for Histopathological Image Analysis.

IEEE access : practical innovations, open solutions·2026
Same journal

Mislabel Identification Using Transfer Learning-Based Ensemble Method.

IEEE access : practical innovations, open solutions·2026
See all related articles

Related Experiment Video

Updated: Oct 17, 2025

Closed-loop Neuro-robotic Experiments to Test Computational Properties of Neuronal Networks
11:18

Closed-loop Neuro-robotic Experiments to Test Computational Properties of Neuronal Networks

Published on: March 2, 2015

10.5K

Software-Defined Workflows for Distributed Interoperable Closed-Loop Neuromodulation Control Systems.

Pradeeban Kathiravelu1, Parisa Sarikhani1, Ping Gu1

  • 1Department of Biomedical Informatics, Emory University, Atlanta, GA 30322, USA.

IEEE Access : Practical Innovations, Open Solutions
|October 11, 2021
PubMed
Summary
This summary is machine-generated.

NEXUS is a new framework for closed-loop neuromodulation systems. It uses Software-Defined Workflows and directed hypergraphs to overcome limitations of traditional systems, enabling flexible and scalable control.

Keywords:
Closed-loop simulationsneuromodulation control systemsworkflow orchestration

More Related Videos

Real-Time Proxy-Control of Re-Parameterized Peripheral Signals using a Close-Loop Interface
11:54

Real-Time Proxy-Control of Re-Parameterized Peripheral Signals using a Close-Loop Interface

Published on: May 8, 2021

4.7K
Using Neuron Spiking Activity to Trigger Closed-Loop Stimuli in Neurophysiological Experiments
05:19

Using Neuron Spiking Activity to Trigger Closed-Loop Stimuli in Neurophysiological Experiments

Published on: November 12, 2019

7.2K

Related Experiment Videos

Last Updated: Oct 17, 2025

Closed-loop Neuro-robotic Experiments to Test Computational Properties of Neuronal Networks
11:18

Closed-loop Neuro-robotic Experiments to Test Computational Properties of Neuronal Networks

Published on: March 2, 2015

10.5K
Real-Time Proxy-Control of Re-Parameterized Peripheral Signals using a Close-Loop Interface
11:54

Real-Time Proxy-Control of Re-Parameterized Peripheral Signals using a Close-Loop Interface

Published on: May 8, 2021

4.7K
Using Neuron Spiking Activity to Trigger Closed-Loop Stimuli in Neurophysiological Experiments
05:19

Using Neuron Spiking Activity to Trigger Closed-Loop Stimuli in Neurophysiological Experiments

Published on: November 12, 2019

7.2K

Area of Science:

  • Computational Neuroscience
  • Systems Biology
  • Bioinformatics

Background:

  • Closed-loop neuromodulation systems require complex, cyclical control flows for regulating physiological processes.
  • Existing workflow frameworks, typically based on directed acyclic graphs (DAGs), lack native support for the cyclical nature of these systems.
  • This limitation hinders the development and deployment of advanced neuromodulation control strategies.

Purpose of the Study:

  • To introduce NEXUS, a novel workflow orchestration framework designed for distributed analytics systems.
  • To enable the creation and management of interoperable closed-loop workflows, overcoming the limitations of DAG-based systems.
  • To demonstrate the framework's capability in executing complex scientific workflows, particularly for neuromodulation control.

Main Methods:

  • NEXUS employs a Software-Defined Workflows approach, separating data and control flows.
  • Workflows are managed through a centralized orchestrator, allowing dynamic composition of microservices.
  • The framework represents workflows using directed hypergraphs (DHGs) instead of DAGs, inherently supporting cycles.

Main Results:

  • NEXUS successfully facilitated the seamless execution of closed-loop neuromodulation control systems.
  • The framework demonstrated feasibility, flexibility, and scalability in modeling and executing cyclical workflows.
  • Evaluations confirmed NEXUS's performance advantages over traditional DAG-based approaches for such applications.

Conclusions:

  • NEXUS provides a robust solution for designing and executing complex, closed-loop scientific workflows.
  • The framework's DHG representation and Software-Defined Workflows approach overcome critical limitations of existing tools.
  • NEXUS is well-suited for advanced applications like neuromodulation, offering enhanced control and system integration.