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Real-time Bioluminescence Imaging of Notch Signaling Dynamics during Murine Neurogenesis
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TAM Signaling in the Nervous System
Tal Burstyn-Cohen1, Arielle Hochberg1
1Institute for Dental Sciences, Faculty of Dental Medicine, The Hebrew University-Hadassah, Jerusalem, Israel.
Brain Plasticity (Amsterdam, Netherlands)
|October 11, 2021
Summary
Tyrosine kinase receptors (TAMs), activated by GAS6 and PROS1, are crucial for nervous system homeostasis, phagocytosis, and repair. Understanding TAM signaling is key to treating neuroinflammation and neurodegeneration.
Area of Science:
- Neuroscience
- Immunology
- Cell Biology
Background:
- Tyro3, Axl, and Mertk form the TAM family of tyrosine kinase receptors.
- TAM receptors are activated by GAS6 and PROS1 ligands.
- TAMs are widely expressed, playing roles in immune, reproductive, vascular, and nervous systems.
Purpose of the Study:
- To review the specific roles of TAM signaling in the nervous system.
- To highlight TAM pathway functions in cell survival, homeostasis, phagocytosis, immunity, and tissue repair.
- To underscore the implications of dysfunctional TAM signaling in neurological disorders.
Main Methods:
- This is a review article, synthesizing existing research.
- Focuses on literature concerning TAM signaling in the nervous system.
- Examines roles in development, homeostasis, and disease states.
Main Results:
- TAM signaling is essential for maintaining nervous system homeostasis.
- Key functions include promoting cell survival and mediating phagocytosis.
- Dysregulation is linked to neuroinflammation and neurodegeneration.
Conclusions:
- TAM signaling is vital for nervous system health and function.
- Understanding TAM pathways is critical for developing therapeutics.
- Further research is needed to fully elucidate TAM signaling mechanisms for therapeutic development.
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