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Updated: Oct 17, 2025
08:19
Induction of Microstreaming by Nonspherical Bubble Oscillations in an Acoustic Levitation System
Published on: May 9, 2021
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Versatile acoustic manipulation of micro-objects using mode-switchable oscillating bubbles: transportation, trapping,
Wei Zhang1, Bin Song1, Xue Bai1
1School of Mechanical Engineering & Automation, Beihang University, Beijing 100191, China. linfeng@buaa.edu.cn.
Lab on a Chip
|October 11, 2021
Summary
This study introduces a bubble-based acoustofluidic device for versatile micro-object manipulation. It enables switchable modes for transportation, trapping, and rotation, enhancing biomedical applications.
Area of Science:
- Microfluidics
- Acoustofluidics
- Biomedical Engineering
Background:
- On-chip micro-object manipulation is crucial for biomedical applications.
- Current devices have fixed designs limiting multifunctional capabilities.
- Need for versatile and controllable micro-manipulation systems.
Purpose of the Study:
- To propose a versatile bubble-based acoustofluidic device for multimodal micro-object manipulation.
- To demonstrate switchable manipulation modes for diverse biomedical applications.
- To enable contactless and biocompatible control of micro-objects.
Main Methods:
- Utilized a bubble-based acoustofluidic device with microcavities.
- Varied applied frequency to switch bubble oscillation modes and streaming patterns.
- Experimentally and numerically verified manipulation modes (transportation, trapping, 3D rotation, circular revolution).
Main Results:
- Achieved flexible switching between four distinct oscillatory motions of bubbles.
- Demonstrated stable transportation, trapping, 3D rotation, and circular revolution of micro-objects.
- Successfully applied mode-switchable manipulation to particles, cells, and organisms noninvasively.
- Developed 3D cell reconstruction using out-of-plane rotational mode.
Conclusions:
- The proposed device offers versatile, controllable, and contactless micro-object manipulation.
- Mode-switchable acoustofluidics provides an efficient solution for biomedical applications.
- Integrated platform simplifies function control and analysis for practical use.
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