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Updated: Oct 17, 2025

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Confusion Approach Modulated Syntheses of Corrorin Parasitized Hexaphyrins(1.1.1.1.1.0) and the Oxidative Ring
Yue Xu1, Bin Zhu1, Qizhao Li1,2
1Key Laboratory for Advanced Materials and Institute of Fine Chemicals, Shanghai Key Laboratory of Functional Materials Chemistry, School of Chemistry & Molecular Engineering, State Key Laboratory of Bioreactor Engineering, Laboratory of Pharmaceutical Crystal Engineering & Technology, School of Pharmacy, East China University of Science & Technology, 200237 Shanghai, China.
Abstract:
A corrorin parasitized hexaphyrin(1.1.1.1.1.0) 1 was synthesized by [4 + 4] condensation, and subsequent treatment with PbO2 afforded hexaphyrin 2 appended with a dipyrrinone moiety via regioselective opening of the corrorin ring. In contrast, oxidation of the corresponding corrorin-N-confused hexaphyrin(1.1.1.1.1.0) hybrid 3 afforded only a keto adduct 4. As a result, the planarity and aromaticity of the hexaphyrin moiety can be modulated.
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