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Promising Protective Effects of Chrysin in Cardiometabolic Diseases

Marjan Talebi1, Mohsen Talebi2,3, Tahereh Farkhondeh4,5

  • 1Department of Pharmacognosy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran 1991953381, Iran.

Current Drug Targets
|October 12, 2021
PubMed

Insights

The natural compound chrysin offers significant protection against cardiometabolic diseases (CMD) by boosting antioxidant defenses and reducing inflammation. Its multifaceted mechanisms combat various CMD risk factors, including diabetes and hypertension.

Area of Science:

  • Cardiovascular Pharmacology
  • Natural Product Chemistry
  • Molecular Medicine

Background:

  • Cardiometabolic diseases (CMD) represent a significant global health burden, characterized by interconnected conditions like type II diabetes, hypertension, dyslipidemia, obesity, and atherosclerosis.
  • The natural flavonoid chrysin is recognized for its diverse therapeutic properties.
  • Understanding chrysin's specific mechanisms against CMD is crucial for developing novel therapeutic strategies.

Purpose of the Study:

  • To investigate the novel cardioprotective mechanisms of the natural flavonoid chrysin against cardiometabolic disorders.
  • To elucidate how chrysin's properties counteract the complex interplay of factors contributing to CMD.
  • To provide an in-depth analysis of chrysin's molecular targets and pathways relevant to cardiovascular health.

Main Methods:

  • Literature review and analysis of existing studies on chrysin's effects on cardiovascular health.
  • Examination of chrysin's impact on antioxidant defense systems and inflammatory pathways.
  • Investigation of chrysin's modulation of key signaling pathways implicated in CMD, including NO, RAS, AGE/RAGE, and PPARs.

Main Results:

  • Chrysin enhances the intrinsic antioxidative defense system, mitigating risks associated with atherosclerosis, vascular dysfunction, hypertension, dyslipidemia, and diabetes-induced injuries.
  • Chrysin exhibits potent anti-inflammatory effects by inhibiting pro-inflammatory pathways such as NF-κB, MAPK, and PI3k/Akt.
  • Chrysin modulates critical pathways including nitric oxide (NO), renin-angiotensin system (RAS), advanced glycation end-products/receptor for advanced glycation end-products (AGE/RAGE), and peroxisome proliferator-activated receptors (PPARs).

Conclusions:

  • Chrysin's cardioprotective effects against cardiometabolic disorders extend beyond simple antioxidation and anti-inflammation.
  • Chrysin targets multiple interconnected pathways, offering a comprehensive approach to managing CMD.
  • The findings highlight chrysin as a promising natural compound for therapeutic interventions in cardiometabolic diseases.

Keywords:
Chrysincardioprotective effectscardiovascular diseasesdiabetes mellitusflavonoidmetabolic syndrome

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