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The Blood-brain Barrier00:49

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Related Experiment Video

Updated: Oct 17, 2025

Analyzing the Permeability of the Blood-Brain Barrier by Microbial Traversal through Microvascular Endothelial Cells
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Breaking down barriers: Tumors make a leaky brain.

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  • 1Brain plasticity in response to the environment, Institut Pasteur, UMR3738, CNRS, 75015 Paris, France.

Developmental Cell
|October 12, 2021
PubMed
Summary

Researchers identified a paraneoplastic syndrome impacting blood-brain barrier permeability and survival in cancer patients. This discovery sheds light on poorly understood mechanisms driving cancer-related conditions outside the tumor itself.

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Area of Science:

  • Oncology
  • Neuroscience
  • Pathology

Background:

  • Cancer patient mortality involves multifactorial causes.
  • Mechanisms driving pathological conditions outside the tumor are poorly understood.

Purpose of the Study:

  • To identify specific paraneoplastic syndromes affecting cancer patient outcomes.
  • To investigate the impact of paraneoplastic syndromes on blood-brain barrier permeability.

Main Methods:

  • Utilized data from Kim et al. (2021) in Developmental Cell.
  • Analyzed mechanisms of paraneoplastic syndromes in cancer.

Main Results:

  • Identified a novel paraneoplastic syndrome.
  • Demonstrated the syndrome's effect on blood-brain barrier permeability.
  • Linked the syndrome to host survival in cancer patients.

Conclusions:

  • Paraneoplastic syndromes represent a significant, understudied aspect of cancer pathology.
  • Understanding these syndromes is crucial for improving cancer patient survival and treatment.