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Updated: Oct 17, 2025

Efficient Synthesis of All-Carbon Quaternary Centers via the Conjugate Addition of Functionalized Monoorganozinc Bromides
Published on: May 26, 2019
Organocatalytic cascade reactions for multi-functionalized chiral cyclic ethers through vinylidene ortho-quinone
Shiqi Jia1, Yu Chang1, Yuhong Tian1
1Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, School of Pharmaceutical Sciences, Chongqing University, Chongqing, 401331, P. R. China. wangpf@cqu.edu.cn.
Abstract:
An organocatalytic approach to installing various alcohols into the carbonyl of α,β-unsaturated ketones mediated by VQM intermediates was achieved, followed by dearomatization to provide the stereo-defined cyclic ethers via a cascade process. Along with the transformations, this strategy affords efficient access to the underexplored chiral cyclic ether chemospace.
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