Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The true costs of data management in the era of data sharing mandates.

Brain injury·2026
Same author

Proteomic blood-based biomarkers of brain damage in traumatic brain injury: are they suitable surrogate endpoints for cerebral pressure autoregulatory-guided therapy?

Critical care (London, England)·2026
Same author

Toward Causal Relationships of Intracranial Pressure, Cerebrovascular Reactivity, Interventions, and Outcome in Severe Traumatic Brain Injury: A CENTER-TBI High-Resolution Substudy.

Neurocritical care·2026
Same author

Machine learning in automatic detection of chordoma signature, postoperative residuals, and prognosis of skull base chordomas.

NPJ precision oncology·2026
Same author

Intracranial compliance monitoring using pulse shape index in traumatic brain injury: relation to cerebral physiology and clinical outcome.

Critical care (London, England)·2026
Same author

Outlining the global variation in resources for traumatic brain injury care: site-level data from the Global Neurotrauma Outcomes Study (GNOS).

BMJ global health·2026

Related Experiment Video

Updated: Oct 17, 2025

Controlled Cortical Impact Model of Mouse Brain Injury with Therapeutic Transplantation of Human Induced Pluripotent Stem Cell-Derived Neural Cells
09:29

Controlled Cortical Impact Model of Mouse Brain Injury with Therapeutic Transplantation of Human Induced Pluripotent Stem Cell-Derived Neural Cells

Published on: July 10, 2019

11.2K

Modeling Brain-Heart Crosstalk Information in Patients with Traumatic Brain Injury.

Giovanna Maria Dimitri1,2, Erta Beqiri3,4, Michal M Placek3,5

  • 1Computer Laboratory, University of Cambridge, Cambridge, UK. giovanna.dimitri@unisi.it.

Neurocritical Care
|October 13, 2021
PubMed
Summary

Brain-heart crosstalks, a novel measure of brain-cardiovascular interaction, are inversely correlated with mortality in traumatic brain injury (TBI) patients. Higher crosstalks indicate better outcomes, suggesting a healthy brain-heart connection is vital for TBI recovery.

Keywords:
CENTER-TBIIntracranial pressureRaised heart rateRaised intracranial pressureTraumatic brain injury

More Related Videos

Systems Analysis of the Neuroinflammatory and Hemodynamic Response to Traumatic Brain Injury
07:21

Systems Analysis of the Neuroinflammatory and Hemodynamic Response to Traumatic Brain Injury

Published on: May 27, 2022

3.3K
Controlled Cortical Impact Model for Traumatic Brain Injury
05:30

Controlled Cortical Impact Model for Traumatic Brain Injury

Published on: August 5, 2014

29.0K

Related Experiment Videos

Last Updated: Oct 17, 2025

Controlled Cortical Impact Model of Mouse Brain Injury with Therapeutic Transplantation of Human Induced Pluripotent Stem Cell-Derived Neural Cells
09:29

Controlled Cortical Impact Model of Mouse Brain Injury with Therapeutic Transplantation of Human Induced Pluripotent Stem Cell-Derived Neural Cells

Published on: July 10, 2019

11.2K
Systems Analysis of the Neuroinflammatory and Hemodynamic Response to Traumatic Brain Injury
07:21

Systems Analysis of the Neuroinflammatory and Hemodynamic Response to Traumatic Brain Injury

Published on: May 27, 2022

3.3K
Controlled Cortical Impact Model for Traumatic Brain Injury
05:30

Controlled Cortical Impact Model for Traumatic Brain Injury

Published on: August 5, 2014

29.0K

Area of Science:

  • Neuroscience
  • Cardiovascular Medicine
  • Critical Care Medicine

Background:

  • Traumatic brain injury (TBI) is a complex condition requiring integrated physiological monitoring.
  • Intracranial pressure (ICP) and heart rate (HR) monitoring provide insights into brain-heart interactions.
  • Understanding these interactions is crucial for optimal patient management.

Purpose of the Study:

  • To investigate simultaneous increases in HR and ICP as indicators of brain-heart interaction.
  • To evaluate novel brain-heart crosstalks (ctnp, mutual information, ωct) in a multicenter TBI cohort.
  • To determine the relationship between these novel indicators and patient mortality.

Main Methods:

  • Utilized complex network modeling to derive brain-heart crosstalks from ICP and HR data.
  • Analyzed data from 226 TBI patients in a multicenter study.
  • Employed Kruskal-Wallis and point biserial correlation tests, followed by logistic regression adjusted for age groups.

Main Results:

  • Statistically significant differences in brain-heart crosstalks were observed between survivors and nonsurvivors (p < 0.05).
  • An inverse correlation was found between novel brain-heart crosstalks measures and mortality.
  • Predictive models incorporating these measures, particularly for specific age groups, explained over 80% of the variance.

Conclusions:

  • A negative relationship exists between brain-heart crosstalks indicators and mortality in TBI.
  • These findings suggest that a healthy brain-cardiovascular interaction is protective in TBI.
  • Novel brain-heart interaction measures show promise for predicting TBI patient outcomes.